Mitigating the impact of adolescence isolation on the development of social anxiety: A potential role for oxytocin.
Mitigating the impact of adolescence isolation on the development of social anxiety: A potential role for oxytocin.
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DOI：
10.3389/fnbeh.2022.1038236
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
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与世隔绝会导致社交焦虑症(SAD)，影响13%的美国人。焦虑症的患病率存在性别差异，因为女性比男性患SAD的比例更高。重要的是，青春期经历的孤立会增加成年后患上SAD的可能性。不幸的是，目前治疗SAD的方法只对50%-65%的患者有效。因此，确定治疗和预防SAD的治疗目标至关重要，特别是在妇女中。在这里，我们讨论童年孤独和成年后的忧郁症之间的联系。接下来，我们考察了用于研究隔离对啮齿动物社交焦虑样行为的影响的临床前模型。来自临床和临床前研究的越来越多的证据表明，催产素信号是改变社交焦虑样行为的潜在靶点。我们提出了性激素影响催产素系统的证据。最后，我们强调了临床和临床前研究的未来方向，以进一步评估催产素作为隔离诱导的SAD的治疗效果。
Exposure to isolation can lead to the development of social anxiety disorder (SAD), which affects 13% of Americans. There are sex differences in the prevalence of anxiety disorders, as women experience higher rates of SAD relative to men. Importantly, isolation experienced during adolescence increases the likelihood of developing SAD in adulthood. Unfortunately, the current treatments for SAD are only effective in 50–65% of patients. As such, it is critical to identify therapeutic targets for the treatment and prevention of SAD, particularly in women. Here, we discuss the links between childhood isolation and adulthood SAD. Next, we examine the preclinical models used to study the impact of isolation on social anxiety-like behaviors in rodents. Increasing evidence from both clinical and pre-clinical studies suggests oxytocin signaling is a potential target to modify social anxiety-like behaviors. We present the evidence that sex hormones influence the oxytocin system. Finally, we highlight future directions for both clinical and pre-clinical studies to further evaluate the efficacy of oxytocin as a treatment for isolation-induced SAD.
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影响因子：
6.6
作者：
Culpin, Iryna;Heuvelman, Hein;Rai, Dheeraj;Pearson, Rebecca M.;Joinson, Carol;Heron, Jon;Evans, Jonathan;Kwong, Alex S. F.
通讯作者：
Kwong, Alex S. F.
影响因子：
4.8
作者：
Garcia-Fernandez, Lorena;Romero-Ferreiro, Veronica;Rodriguez, Victoria;Alvarez-Mon, Miguel A.;Lahera, Guillermo;Rodriguez-Jimenez, Roberto
通讯作者：
Rodriguez-Jimenez, Roberto
影响因子：
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作者：
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通讯作者：
Wittchen, Hans-Ulrich
影响因子：
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作者：
Gottschalk, Michael G;Domschke, Katharina
通讯作者：
Domschke, Katharina
影响因子：
3.7
作者：
Graham, Bronwyn M.;Shin, Geena
通讯作者：
Shin, Geena