Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients.
Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients.
复制标题
DOI：
10.1111/jdi.12792
复制
发表时间：
2018-07
影响因子：
3.2
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Hong BS;Liu J;Zheng J;Ke W;Huang Z;Wan X;He X;Xiao H;Li Y
探讨不同程度非酒精性脂肪性肝病(NAFLD)患者血清血管生成素样蛋白8(ANGPTL-8)水平及其与肝细胞脂含量(HCL)和胰岛素抵抗的关系。入选48名成人，其中12人无酒精性脂肪肝(组1)，18例轻度酒精性脂肪肝(5.5%≤≥)10.0%(组2)，18例中重度酒精性脂肪肝(组3)。所有受试者的外周胰岛素敏感性通过高胰岛素-正常血糖钳夹(M值)以及HCL的磁共振图像进行监测。研究中还记录了血清ANGPTL-8、血糖水平和血脂谱。与第1组和第2组相比，第3组的代谢谱更差，ANGPTL8水平最高(1129±351pg/mLvs742±252pg/mL765±301pg/mL，P=0.001)。在所有代谢谱中，盐酸与ANGPTL8的相关性最强(r=0.436，P=0.042)。多元逐步线性回归分析显示，血管紧张素转换酶8和丙氨酸氨基转移酶是高脂血症的独立决定因素(P=0.002，P<0.001)，这两个指标可解释高脂血症的67.4%(P<0.001)。ANGPTL-8与肝细胞脂质含量呈正相关，不受肥胖和胰岛素抵抗的影响，提示ANGPTL-8可能是预测NAFLD严重程度的一个新的重要指标。
To explore angiopoietin‐like protein 8 (ANGPTL‐8) levels, and its association with hepatocellular lipid content (HCL) and insulin resistance in patients with different extents of non‐alcoholic fatty liver disease (NAFLD). In 48 adults were recruited, of which 12 had no NAFLD (HCL < 5.5%; group 1), 18 had mild NAFLD (5.5% ≤ HCL < 10.0%; group 2) and 18 had moderate‐to‐severe NAFLD (HCL ≥ 10.0%; group 3). The peripheral insulin sensitivity of all participants was monitored by a hyperinsulinemic‐euglycemic clamp (M value), as well as the magnetic resonance image of HCL. Serum ANGPTL‐8, blood glucose levels and lipid profiles were also recorded in the study. Group 3 had a worse metabolic profile, and had the highest ANGPTL‐8 level (1,129 ± 351 pg/mL vs 742 ± 252 pg/mL, 765 ± 301 pg/mL, P = 0.001) compared with those in group 1 and group 2. In all metabolic profiles, HCL positively correlated the strongest with ANGPTL‐8 (r = 0.436, P = 0.042). Multivariate stepwise linear regression analysis showed ANGPTL‐8 and alanine aminotransferase were independent determinants of HCL (P = 0.002, P < 0.001, respectively), and these two indexes explained 67.4% of the variation of HCL (P < 0.001). ANGPTL‐8 was positively correlated with hepatocellular lipid content independent of obesity and insulin resistance, indicating that ANGPTL‐8 might be a new and important important predictor of the severity of NAFLD.
登录
查看更多内容
人类 2 型糖尿病和肥胖症中循环脂肪酶/β-肌营养蛋白升高。
影响因子：
4.6
作者：
Fu Z;Berhane F;Fite A;Seyoum B;Abou-Samra AB;Zhang R
通讯作者：
Zhang R
影响因子：
8.2
作者：
Espes, Daniel;Lau, Joey;Carlsson, Per-Ola
通讯作者：
Carlsson, Per-Ola
中国酒精性和非酒精性脂肪肝流行病学
影响因子：
4.1
作者：
Fan, Jian-Gao
通讯作者：
Fan, Jian-Gao
DOI：
10.1152/ajpendo.00084.2012
发表时间：
2012-08-01
影响因子：
5.1
作者：
Ren, Gang;Kim, Ji Young;Smas, Cynthia M.
通讯作者：
Smas, Cynthia M.
DOI：
10.1073/pnas.1217552109
发表时间：
2012-11-27
影响因子：
11.1
作者：
Quagliarini, Fabiana;Wang, Yan;Hobbs, Helen H.
通讯作者：
Hobbs, Helen H.