CNS-Spleen Axis - a Close Interplay in Mediating Inflammatory Responses in Burn Patients and a Key to Novel Burn Therapeutics.
CNS-Spleen Axis - a Close Interplay in Mediating Inflammatory Responses in Burn Patients and a Key to Novel Burn Therapeutics.
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DOI：
10.3389/fimmu.2021.720221
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发表时间：
2021
影响因子：
7.3
通讯作者：
Jeschke MG
中科院分区：
文献类型：
--
作者：
Khan N;Kaur S;Knuth CM;Jeschke MG
严重烧伤引起的炎症反应和随后的高代谢反应可导致严重感染和脓毒症，导致患者多器官功能衰竭和高死亡率。这对临床医生来说是一个极具挑战性的问题，因为脓毒症是烧伤患者死亡的主要原因。由于炎症过度和免疫功能障碍是免疫失衡的结果，恢复这些条件似乎对烧伤患者有希望的好处。调节免疫平衡的关键网络是中枢神经系统（CNS）-脾轴，其协调多个信号传导途径，包括交感神经和副交感神经途径。调节炎症是研究人员用于了解其他炎症过度疾病模型中神经免疫调节的关键策略，调节CNS-脾轴可以改善患者的临床结局。由于免疫平衡对于烧伤引起的脓毒症和炎症反应过度的患者的恢复至关重要，因此严重烧伤似乎会显著改变CNS-脾轴。因此，有必要解决和讨论潜在的治疗技术，目标是中枢神经系统-脾轴，旨在恢复烧伤患者的稳态。为了详细了解这一点，我们进行了一项系统综述，探讨CNS-脾轴的作用及其对烧伤诱导的高代谢反应和相关脓毒症并发症的免疫调节的影响。此外，这一彻底的审查探讨了脾，中枢神经系统脾轴的作用，在低潮和流动阶段严重烧伤后，这个轴如何诱导代谢因素和免疫功能障碍，和治疗技术和化学干预，通过神经免疫调节恢复免疫平衡。
Severe burn-induced inflammation and subsequent hypermetabolic response can lead to profound infection and sepsis, resulting in multiple organ failure and high mortality risk in patients. This represents an extremely challenging issue for clinicians as sepsis is the leading cause of mortality in burn patients. Since hyperinflammation and immune dysfunction are a result of an immune imbalance, restoring these conditions seem to have promising benefits for burn patients. A key network that modulates the immune balance is the central nervous system (CNS)-spleen axis, which coordinates multiple signaling pathways, including sympathetic and parasympathetic pathways. Modulating inflammation is a key strategy that researchers use to understand neuroimmunomodulation in other hyperinflammatory disease models and modulating the CNS-spleen axis has led to improved clinical outcomes in patients. As the immune balance is paramount for recovery in burn-induced sepsis and patients with hyperinflammatory conditions, it appears that severe burn injuries substantially alter this CNS-spleen axis. Therefore, it is essential to address and discuss the potential therapeutic techniques that target the CNS-spleen axis that aim to restore homeostasis in burn patients. To understand this in detail, we have conducted a systematic review to explore the role of the CNS-spleen axis and its impact on immunomodulation concerning the burn-induced hypermetabolic response and associated sepsis complications. Furthermore, this thorough review explores the role of the spleen, CNS-spleen axis in the ebb and flow phases following a severe burn, how this axis induces metabolic factors and immune dysfunction, and therapeutic techniques and chemical interventions that restore the immune balance via neuroimmunomodulation.
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影响因子：
16.6
作者：
Carnevale, Daniela;Perrotta, Marialuisa;Pallante, Fabio;Fardella, Valentina;Iacobucci, Roberta;Fardella, Stefania;Carnevale, Lorenzo;Carnevale, Raimondo;De Lucia, Massimiliano;Cifelli, Giuseppe;Lembo, Giuseppe
通讯作者：
Lembo, Giuseppe
α7烟碱受体是基于炎症疾病的新型治疗靶标。
影响因子：
8
作者：
Bencherif, Merouane;Lippiello, Patrick M.;Lucas, Rudolf;Marrero, Mario B.
通讯作者：
Marrero, Mario B.
DOI：
10.1097/shk.0000000000000752
发表时间：
2017-02
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Holmes CJ;Plichta JK;Gamelli RL;Radek KA
通讯作者：
Radek KA
影响因子：
3.7
作者：
Borges, Uirassu;Laborde, Sylvain;Raab, Markus
通讯作者：
Raab, Markus
影响因子：
32.4
作者：
Adrover, Jose M.;del Fresno, Carlos;Hidalgo, Andres
通讯作者：
Hidalgo, Andres