Backbone-Degradable Polymers Prepared by Chemical Vapor Deposition.
Backbone-Degradable Polymers Prepared by Chemical Vapor Deposition.
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DOI：
10.1002/anie.201609307
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发表时间：
2017-01-02
期刊：
影响因子：
--
通讯作者：
Lahann J
中科院分区：
文献类型：
--
作者：
Xie F;Deng X;Kratzer D;Cheng KC;Friedmann C;Qi S;Solorio L;Lahann J
通过化学气相沉积（CVD）聚合制备的聚合物在研究和工业应用中已被广泛接受。然而，它们固有的缺乏降解性限制了它们在许多领域的广泛应用，例如生物医学设备或再生医学。在此，我们首次展示了通过CVD直接合成的主链可降解聚合物。[2.2]对-环番与环状烯酮缩醛，特别是5，6-苯并-2-亚甲基-1，3-二氧杂环庚烷（BMDO）的CVD共聚产生定义明确的水解可降解聚合物，如通过FTIR光谱和椭圆偏振法所证实的。降解动力学取决于烯酮缩醛与[2.2]对环番的比例以及膜的疏水性。这些涂层解决了生物医学聚合物领域中未满足的需求，因为它们提供了获得将联合收割机界面多功能性与可降解性相结合的广泛的反应性聚合物涂层的途径。采用化学气相沉积共聚法制备了一类新型主链可降解聚合物涂料。这些聚合物涂层解决了生物医学聚合物领域中显著的未满足的需求，因为它们提供了获得广泛的反应性聚合物涂层的途径，所述反应性聚合物涂层将联合收割机界面多功能性与可降解性相结合。
Polymers prepared by chemical vapor deposition (CVD) polymerization have found broad acceptance in research and industrial applications. However, their intrinsic lack of degradability has limited wider applicability in many areas, such as biomedical devices or regenerative medicine. Herein, we demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD. The CVD co-polymerization of [2.2]para-cyclophanes with cyclic ketene acetals, specifically 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy and ellipsometry. The degradation kinetics are dependent on the ratio of ketene acetals to [2.2]para-cyclophanes as well as the hydrophobicity of the films. These coatings address an unmet need in the biomedical polymer field, as they provide access to a wide range of reactive polymer coatings that combine interfacial multifunctionality with degradability. A new class of backbone-degradable polymer coatings was developed via chemical vapor deposition co-polymerization. These polymer coatings address a significant unmet need in the biomedical polymer field, as they provide access to a wide range of reactive polymer coatings that combine interfacial multifunctionality with degradability.
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