MicroRNA roles in beta-catenin pathway.
MicroRNA roles in beta-catenin pathway.
复制标题
MicroRNA 在 β-catenin 通路中的作用。
DOI:
10.1186/1476-4598-9-252
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发表时间:
2010-09-21
期刊:
影响因子:
37.3
通讯作者:
Kang CS
中科院分区:
文献类型:
--
作者:
Huang K;Zhang JX;Han L;You YP;Jiang T;Pu PY;Kang CS
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.
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