Alpha 1-adrenoreceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery.
Alpha 1-adrenoreceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery.
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α1-肾上腺素受体阻滞剂可减少大鼠胸主动脉和颈动脉中血管紧张素 II 诱导的血管平滑肌细胞 DNA 合成。
DOI：
10.1161/01.res.70.6.1122
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发表时间：
1992
影响因子：
20.1
通讯作者：
Daemen,MJ
中科院分区：
文献类型：
--
作者：
vanKleef,EM;Smits,JF;DeMey,JG;Cleutjens,JP;Lombardi,DM;Schwartz,SM;Daemen,MJ
我们探讨了α 1肾上腺素受体阻滞剂哌唑嗪对血管紧张素II（Ang II）诱导的大鼠血管平滑肌细胞（SMC）DNA合成增加的影响。血管紧张素II与或不与哌唑嗪或其溶剂。将观察结果与接受生理盐水或溶剂的大鼠进行比较。A组皮下植入微渗透泵，以35 ng/100 g/min的速度持续输注Ang Ⅱ 2周。B组给予Ang Ⅱ和α 1肾上腺素受体拮抗剂哌唑嗪（0.35 μ g/100 g/min）。C组接受Ang II和50%二甲基亚砜（DMSO），哌唑嗪的溶剂，D组接受50% DMSO，E组接受0.9% NaCl（Ang II溶剂）。通过单独的微型泵向所有动物输注5-溴-2 '-脱氧尿苷2周以测量DNA合成。Ang II显著增加胸主动脉中膜中DNA合成SMC的分数，从E组（n = 6）的0.4 +/- 0.1%（平均值+/- SD）增加到A组（n = 8）的10.8 +/- 7.0%。在Ang II中加入哌唑嗪使SMC的标记分数降低至3.0 ± 2.2%（组B，n = 9）。哌唑嗪处理组中剩余的SMC DNA合成可能是由于哌唑嗪溶剂的作用，即，50%DMSO，因为单独输注50%DMSO将标记分数增加至4.1 +/- 2.0%（D组，n = 6）。（250字处删节）
We explored effects of alpha 1-adrenoreceptor blockade with prazosin on the increased vascular smooth muscle cell (SMC) DNA synthesis induced by angiotensin II (Ang II) in rats. Ang II was infused with or without prazosin or its solvent. Observations were compared with those in rats receiving saline or solvent. In group A, Ang II was infused for 2 weeks by subcutaneously implanted osmotic minipumps at a rate of 35 ng/100 g per minute. Group B received Ang II together with the alpha 1-adrenoreceptor antagonist prazosin (0.35 micrograms/100 g per minute). Group C received Ang II and 50% dimethyl sulfoxide (DMSO), the solvent of prazosin; group D received 50% DMSO; and group E received 0.9% NaCl (Ang II vehicle). All animals were infused with 5-bromo-2'-deoxyuridine for 2 weeks via separate minipumps to measure DNA synthesis. Ang II significantly increased the fraction of DNA synthesizing SMCs in the media of the thoracic aorta from 0.4 +/- 0.1% (mean +/- SD) in group E (n = 6) to 10.8 +/- 7.0% in group A (n = 8). Addition of prazosin to Ang II reduced the labeling fraction of SMCs to 3.0 +/- 2.2% (group B, n = 9). The remaining SMC DNA synthesis in the prazosin-treated group was probably due to the effects of the solvent of prazosin, i.e., 50% DMSO, since infusion of 50% DMSO alone increased the labeling fraction to 4.1 +/- 2.0% (group D, n = 6).(ABSTRACT TRUNCATED AT 250 WORDS)
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DOI：
--
发表时间：
2006
期刊：
総務省統計研修所 リサーチペーパー 第5号
影响因子：
--
作者：
元山 斉;山口 幸三;ryoko Morozumi;美添泰人・荒木万寿夫
通讯作者：
美添泰人・荒木万寿夫
影响因子：
158.5
作者：
LIBBY, P;WARNER, SJC;BIRINYI, LK
通讯作者：
BIRINYI, LK
哌唑嗪抑制兔内皮剥脱后内膜增生的作用
影响因子：
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作者：
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通讯作者：
N. O’higgins
儿茶酚胺对培养的大鼠主动脉平滑肌细胞的生长刺激作用
影响因子：
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作者：
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通讯作者：
J. Boissel
钙拮抗剂对球囊导管诱导的动脉平滑肌细胞增殖和病变大小的抑制作用。
影响因子：
5.3
作者：
C. Jackson;R. Bush;D. Bowyer
通讯作者：
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