Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow.
Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow.
复制标题
DOI：
10.1016/j.neuroimage.2023.120039
复制
发表时间：
2023-05-01
期刊：
影响因子：
5.7
通讯作者：
Qin, Qin
中科院分区：
文献类型：
--
作者：
Xu, Feng;Liu, Dapeng;Zhu, Dan;Hillis, Argye E.;Bakker, Arnold;Soldan, Anja;Albert, Marilyn S.;Lin, Doris D. M.;Qin, Qin
关键词：
基于速度选择性反转（VSI）的速度选择性动脉自旋标记（VSASL）技术已发展成为一种测量脑血流（CBF）的新技术，它对动脉通过时间的延长敏感性低，对脑灌注信号的敏感性高。本磁共振成像研究的目的是评价VSI准备的3D VSASL协议的重测信度，该协议具有全脑覆盖范围，以检测不同脑区认知正常参与者的基线CBF变化。计算扫描或会话、受试者和灰质区域的绝对和相对CBF的变异系数（CoV），并计算相应的组内相关系数（ICC）。绝对CBF的受试者间CoV（13.4±2.0%）高于受试者内CoV（会话内：3.8±1.1%;会话间：4.9±0.9%），产生了中度至极好的ICC（会话内：0.88±0.08;会话间：0.77±0.14），以检测个体CBF的正常变化。相对CBF的区域间CoV（11.4±3.0%）高于区域内CoV（会话内：2.3±0.9%;会话间：3.3±1.0%），产生了极好的ICC（会话内：0.92±0.06;会话间：0.85±0.12）来检测区域CBF的正常变化。年龄、血压、潮气末CO2和红细胞压积部分解释了受试者之间CBF的变异性。总之，这些结果表明，VSASL检测受试者之间和地区之间的变化，支持其临床实用性的良好的重测信度。
Velocity-selective inversion (VSI) based velocity-selective arterial spin labeling (VSASL) has been developed to measure cerebral blood flow (CBF) with low susceptibility to the prolonged arterial transit time and high sensitivity to brain perfusion signal. The purpose of this magnetic resonance imaging study is to evaluate the test-retest reliability of a VSI-prepared 3D VSASL protocol with whole-brain coverage to detect baseline CBF variations among cognitively normal participants in different brain regions. Coefficients of variation (CoV) of both absolute and relative CBF across scans or sessions, subjects, and gray matter regions were calculated, and corresponding intraclass correlation coefficients (ICC) were computed. The higher between-subject CoV of absolute CBF (13.4±2.0%) over within-subject CoV (within-session: 3.8±1.1%; between-session: 4.9±0.9%) yielded moderate to excellent ICC (within-session: 0.88±0.08; between-session: 0.77±0.14) to detect normal variations of individual CBF. The higher between-region CoV of relative CBF (11.4±3.0%) over within-region CoV (within-session: 2.3±0.9%; between-session: 3.3±1.0%) yielded excellent ICC (within-session: 0.92±0.06; between-session: 0.85±0.12) to detect normal variations of regional CBF. Age, blood pressure, end-tidal CO2, and hematocrit partially explained the variability of CBF across subjects. Together these results show excellent test-retest reliability of VSASL to detect both between-subject and between-region variations supporting its clinical utility.
登录
查看更多内容
影响因子：
3.5
作者：
Baas, K. P. A.;Petr, J.;van de Ven, K. C. C.
通讯作者：
van de Ven, K. C. C.
影响因子：
19.7
作者：
Jain, Varsha;Duda, Jeffrey;Wang, Danny J. J.
通讯作者：
Wang, Danny J. J.
影响因子：
3.3
作者：
Duhamel, G;de Bazelaire, U;Alsop, DC
通讯作者：
Alsop, DC
影响因子：
6.3
作者：
Henriksen, Otto M.;Kruuse, Christina;Rostrup, Egill
通讯作者：
Rostrup, Egill
影响因子：
6.3
作者：
Jiang, Dengrong;Lin, Zixuan;Lu, Hanzhang
通讯作者：
Lu, Hanzhang