DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy.
DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy.
复制标题
DEAD-Box RNA 解旋酶在细胞周期控制和临床治疗中的应用
作者：
Zhang L;Li X
细胞周期通过许多信号通路调节，这些信号通路决定细胞是否增殖、保持静止、停滞或经历凋亡。细胞周期调节异常与许多疾病有关。因此，迫切需要了解细胞周期如何控制的不同分子机制。RNA解旋酶是一个蛋白质大家族，在RNA代谢的各个方面都有功能，包括RNA分子的解旋或退火以调节前mRNA、rRNA和miRNA加工，RNA上的蛋白质复合物的夹持，或重塑核糖核蛋白复合物，以调节基因表达。RNA解旋酶还通过直接相互作用调节特定蛋白质的活性。RNA解旋酶的异常表达与不同的疾病相关，包括癌症、神经系统疾病、衰老和常染色体显性多囊肾病（ADPKD），其通过调节多种细胞过程如细胞增殖、细胞周期停滞和细胞凋亡。最近的研究表明，RNA解旋酶参与调控细胞周期的各个阶段，包括G1-S转换，S期，G2-M转换，有丝分裂和胞质分裂。本文就RNA解旋酶在细胞周期不同阶段的调控中的重要作用和机制进行综述。为此，RNA解旋酶为治疗或预防药物的开发提供了丰富的靶标来源。我们还讨论了针对RNA解旋酶的不同靶向策略、探索的不同类型的化合物、化合物对特定RNA解旋酶的拟议抑制机制以及这些化合物在治疗各种疾病中的治疗潜力。
Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases. Thus, there is an urgent need to understand the diverse molecular mechanisms of how the cell cycle is controlled. RNA helicases constitute a large family of proteins with functions in all aspects of RNA metabolism, including unwinding or annealing of RNA molecules to regulate pre-mRNA, rRNA and miRNA processing, clamping protein complexes on RNA, or remodeling ribonucleoprotein complexes, to regulate gene expression. RNA helicases also regulate the activity of specific proteins through direct interaction. Abnormal expression of RNA helicases has been associated with different diseases, including cancer, neurological disorders, aging, and autosomal dominant polycystic kidney disease (ADPKD) via regulation of a diverse range of cellular processes such as cell proliferation, cell cycle arrest, and apoptosis. Recent studies showed that RNA helicases participate in the regulation of the cell cycle progression at each cell cycle phase, including G1-S transition, S phase, G2-M transition, mitosis, and cytokinesis. In this review, we discuss the essential roles and mechanisms of RNA helicases in the regulation of the cell cycle at different phases. For that, RNA helicases provide a rich source of targets for the development of therapeutic or prophylactic drugs. We also discuss the different targeting strategies against RNA helicases, the different types of compounds explored, the proposed inhibitory mechanisms of the compounds on specific RNA helicases, and the therapeutic potential of these compounds in the treatment of various disorders.
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影响因子：
1.9
作者：
Botlagunta M;Kollapalli B;Kakarla L;Gajarla SP;Gade SP;Dadi CL;Penumadu A;Javeed S
通讯作者：
Javeed S
影响因子：
7.5
作者：
Cordin, Olivier;Hahn, Daniela;Beggs, Jean D.
通讯作者：
Beggs, Jean D.
DOI：
10.1073/pnas.0504249102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Bordeleau, ME;Matthews, J;Pelletier, J
通讯作者：
Pelletier, J
影响因子：
3.3
作者：
Chen, Wenjun;Hu, Yabing;Lee, Heng-Chi
通讯作者：
Lee, Heng-Chi
影响因子：
11.2
作者：
Chao, Chi-Hong;Chen, Chun-Ming;Lee, Yan-Hwa Wu
通讯作者：
Lee, Yan-Hwa Wu