Estimating retrospective exposure of household humidifier disinfectants.
Estimating retrospective exposure of household humidifier disinfectants.
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DOI：
10.1111/ina.12180
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发表时间：
2015-12
期刊：
影响因子：
5.8
通讯作者：
Paek DM
中科院分区：
文献类型：
--
作者：
Park DU;Friesen MC;Roh HS;Choi YY;Ahn JJ;Lim HK;Kim SK;Koh DH;Jung HJ;Lee JH;Cheong HK;Lim SY;Leem JH;Kim YH;Paek DM
我们对374名假定其疾病与湿化器消毒剂使用相关的肺部疾病受试者（患者组）及其303名家庭成员（家庭组）进行了全面的湿化器消毒剂暴露表征，以进行正在进行的流行病学研究。我们访问了登记患者的家庭，调查消毒剂的使用特点。根据调查问卷和来自照片的支持性证据（证明使用湿化器消毒剂、消毒剂购买收据、任何残留消毒剂及其声明的一致性）确定暴露于消毒剂的概率。暴露持续时间估计为调查问卷中的累积消毒剂使用小时数。根据每天添加到湿化器中的消毒剂体积（mL）和频率、消毒剂散装水平（μg/mL）、含湿化器消毒剂的房间体积（m3）和通风程度，估计空气中消毒剂暴露强度（μg/m3）。总体而言，患者组的湿化器消毒剂暴露强度、持续时间和累积暴露量的分布模式均高于家庭组，尤其是孕妇和≤ 6岁的患者。进一步的研究正在进行中，以评估此处估计的消毒剂暴露与临床诊断的肺部疾病之间的关联。
We conducted a comprehensive humidifier disinfectant exposure characterization for 374 subjects with lung disease who presumed their disease was related to humidifier disinfectant use (patient group) and for 303 of their family members (family group) for an ongoing epidemiological study. We visited the homes of the registered patients to investigate disinfectant use characteristics. Probability of exposure to disinfectants was determined from the questionnaire and supporting evidence from photographs demonstrating the use of humidifier disinfectant, disinfectant purchase receipts, any residual disinfectant and the consistency of their statements. Exposure duration was estimated as cumulative disinfectant use hours from the questionnaire. Airborne disinfectant exposure intensity (μg/m3) was estimated based on the disinfectant volume (mL) and frequency added to the humidifier per day, disinfectant bulk level (μg/mL), the volume of the room (m3) with humidifier disinfectant, and the degree of ventilation. Overall, the distribution patterns of the intensity, duration and cumulative exposure to humidifier disinfectants for the patient group were higher than those of the family group, especially for pregnant women and patients ≤ 6 years old. Further study is underway to evaluate the association between the disinfectant exposure estimated here with clinically diagnosed lung disease.
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影响因子：
3.7
作者：
Yang HJ;Kim HJ;Yu J;Lee E;Jung YH;Kim HY;Seo JH;Kwon GY;Park JH;Gwack J;Youn SK;Kwon JW;Jun BY;Kim KW;Ahn K;Lee SY;Park JD;Kwon JW;Kim BJ;Lee MS;Do KH;Jang SJ;Pyun BY;Hong SJ
通讯作者：
Hong SJ
DOI：
10.1038/sj.jea.7500345
发表时间：
2004-11-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
King, WD;Dodds, L;Nimrod, C
通讯作者：
Nimrod, C
影响因子：
9.6
作者：
SUDA, T;SATO, A;CHIDA, K
通讯作者：
CHIDA, K
影响因子：
10.4
作者：
Shin HM;Vieira VM;Ryan PB;Steenland K;Bartell SM
通讯作者：
Bartell SM
影响因子：
3.5
作者：
STEWART, PA;STEWART, WF
通讯作者：
STEWART, WF