Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project.
Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project.
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DOI：
10.1289/ehp.1103729
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发表时间：
2011-12
影响因子：
10.4
通讯作者：
Bartell SM
中科院分区：
文献类型：
--
作者：
Shin HM;Vieira VM;Ryan PB;Steenland K;Bartell SM
背景资料：生活或工作在俄亥俄州东部和西弗吉尼亚州西部的人们暴露于杜邦华盛顿工厂释放的全氟辛酸（PFOA）。目的：我们的目标是估计历史PFOA暴露和血清浓度经历的45,276非职业暴露的参与者在C8健康项目谁同意分享他们的居住历史和2005-2006年血清PFOA测量。研究方法：我们估计每个人的年PFOA暴露率的基础上预测校准水浓度和预测的空气浓度使用环境命运和运输模型，个人的居住历史，和公共供水网络的地图。我们将个体暴露估计值与一室吸收、分布、代谢和排泄（ADME）模型相结合，以估计时间依赖性血清浓度。结果如下：对于所有参与者（n = 45，276），2005-2006年的预测和观察中位血清浓度分别为14.2和24.3 ppb [斯皮尔曼秩相关系数（rs）= 0.67]。对于提供每日公共井水消耗率的参与者，以及在血清样本之前5年在六个市政水区之一具有相同住所和工作场所的参与者（n = 1，074），2005-2006年的预测和观察中位血清浓度分别为32.2和40.0 ppb（rs = 0.82）。结论：血清PFOA浓度预测的联系接触和ADME模型与观察到的2005-2006年C8健康项目参与者的人血清浓度相关。这些个体化的回顾性暴露和血清估计值正用于该地区正在进行的各种流行病学研究。
Background: People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities. Objectives: Our objective was to estimate historical PFOA exposures and serum concentrations experienced by 45,276 non-occupationally exposed participants in the C8 Health Project who consented to share their residential histories and a 2005–2006 serum PFOA measurement. Methods: We estimated annual PFOA exposure rates for each individual based on predicted calibrated water concentrations and predicted air concentrations using an environmental fate and transport model, individual residential histories, and maps of public water supply networks. We coupled individual exposure estimates with a one-compartment absorption, distribution, metabolism, and excretion (ADME) model to estimate time-dependent serum concentrations. Results: For all participants (n = 45,276), predicted and observed median serum concentrations in 2005–2006 are 14.2 and 24.3 ppb, respectively [Spearman’s rank correlation coefficient (rs) = 0.67]. For participants who provided daily public well water consumption rate and who had the same residence and workplace in one of six municipal water districts for 5 years before the serum sample (n = 1,074), predicted and observed median serum concentrations in 2005–2006 are 32.2 and 40.0 ppb, respectively (rs = 0.82). Conclusions: Serum PFOA concentrations predicted by linked exposure and ADME models correlated well with observed 2005–2006 human serum concentrations for C8 Health Project participants. These individualized retrospective exposure and serum estimates are being used in a variety of epidemiologic studies being conducted in this region.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
11.4
作者：
McMurdo, Colin J.;Ellis, David A.;Reid, Liisa K.
通讯作者：
Reid, Liisa K.
影响因子：
8.9
作者：
Kim, Seung-Kyu;Lee, Kyu Tae;Lee, Jong-Hyeon
通讯作者：
Lee, Jong-Hyeon
影响因子：
12.8
作者：
Loganathan, Bommanna G.;Sajwan, Kenneth S.;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
11.4
作者：
Fromme, Hermann;Mosch, Christine;Volkel, Wolfgang
通讯作者：
Volkel, Wolfgang