Nasal-type NK/T cell lymphoma: clinical features and treatment outcome.
Nasal-type NK/T cell lymphoma: clinical features and treatment outcome.
复制标题
鼻型NK/T细胞淋巴瘤：临床特征和治疗结果。
DOI：
10.1038/sj.bjc.6602502
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发表时间：
2005-04-11
影响因子：
8.8
通讯作者：
Park, K
中科院分区：
文献类型：
--
作者：
Lee, J;Kim, WS;Park, YH;Park, SH;Park, KW;Kang, JH;Lee, SS;Lee, SI;Lee, SH;Kim, K;Jung, CW;Ahn, YC;Ko, YH;Park, K
鼻型NK/T细胞淋巴瘤是一种越来越被认可的具有侵袭性临床行为的疾病实体。本研究的目的是探讨鼻型NK/T细胞淋巴瘤患者的临床特征和治疗结果。1991年1月至2003年12月，26例鼻型NK/T细胞淋巴瘤患者被纳入分析。一半患者表现为体能状态较差（ECOG ≥ 2）; 46%的患者根据IPI被归类为高、中或高风险组; 46%的患者被诊断为晚期。26例鼻型NK/T细胞淋巴瘤患者的中位生存期为7.4个月（95%CI，0.1，16.9）。以蒽环类为主的原发性化疗的治疗结局较差：局部疾病的CR率为60%，晚期疾病的CR率为0%。在达到CR（范围29.6-165.7）的局部疾病患者中，中位随访24.4个月（范围3.1-99.0）后，3例患者（50.0%）分别在6.1、21.8和52.1个月时出现疾病复发，所有患者均出现局部失败。多因素分析显示，年龄大于60岁、晚期和临床表现差是生存不良的预测因素。总之，鼻型NK/T细胞淋巴瘤对传统的蒽环类药物化疗反应较差，因此迫切需要研究一种创新的治疗方法来提高这些患者的生存率。
Nasal-type NK/T cell lymphoma is an increasingly recognised disease entity of aggressive clinical behaviour. The objective of this study was to investigate clinical features and treatment outcomes in patients with nasal-type NK/T cell lymphoma. From January 1991 to December 2003, 26 patients diagnosed as nasal-type NK/T cell lymphoma were included in the analysis. One half of patients presented with poor performance status (ECOG ⩾2); 46% of patients were categorised as high intermediate or high-risk group according to IPI; and 46% of patients were diagnosed at advanced stage. The median survival for 26 patients with nasal-type NK/T cell lymphoma was 7.4 months (95% CI, 0.1, 16.9). The treatment outcome of primary anthracycline-based chemotherapy was poor: 60% CR rate in localised disease and 0% CR rate in advanced disease. After a median follow-up of 24.4 months (range 3.1–99.0) in patients with localised disease who had achieved a CR (range 29.6–165.7), three patients (50.0%) developed disease recurrence at 6.1, 21.8, and 52.1 months, respectively, and all patients presented with locoregional failure. The predictive factors for poor survival were of age greater than 60, advanced stage and poor performance in multivariate analysis. In conclusion, Nasal-type NK/T cell lymphomas showed a poor response to the conventional anthracycline-based chemotherapy, and thus an investigation for an innovative therapy is urgently needed to improve survival in these patients.
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影响因子：
6.4
作者：
Kobashi, Y;Nakamura, S;Suchi, T
通讯作者：
Suchi, T
影响因子：
45.3
作者：
Mraz-Gernhard, S;Natkunam, Y;Kim, YH
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Kim, YH
DOI：
10.1016/s0190-9622(99)70204-5
发表时间：
1999-02-01
影响因子：
13.8
作者：
Hirakawa, S;Kuyama, H;Arata, J
通讯作者：
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影响因子：
50.5
作者：
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通讯作者：
Park, K
影响因子：
3.3
作者：
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通讯作者：
CHEUNG, MMC