Race-specific type 1 diabetes risk of HLA-DR7 haplotypes.
Race-specific type 1 diabetes risk of HLA-DR7 haplotypes.
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DOI：
10.1111/j.1399-0039.2011.01772.x
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Valdes AM
中科院分区：
文献类型：
--
作者：
Noble JA;Johnson J;Lane JA;Valdes AM
为了验证来自欧洲和非洲人群的含有DRB1*07:01基因的密切相关的HLA单倍型（“DR7”单倍型）对1型糖尿病（T1D）的遗传易感性存在差异的假设，这取决于存在的DQ-α分子。来自1型糖尿病遗传学协会和奥克兰儿童医院和研究中心的98名非裔美国T1D患者进行了HLA II类位点DRB1、DQA1和DQB1的基因分型。从加利福尼亚出生的非洲裔美国人的新生儿血液斑点卡中提取的DNA样本（n=947）被用作以人群为基础的对照组。在非裔美国人中，来自欧洲的DRB1*07:01-DQA1*02:01-DQB1*02:01g单倍型对T1D风险具有保护作用(优势比(OR)=0.34；95% ci 0.14 - 0.78；p<0.011)，而来自非洲的DRB1*07:01-DQA1*03:01-DQB1*02:01g单倍型增加了T1D风险（OR=3.96; 95% CI 1.94 - 8.08; p<5.5E-05）。DRB1*07:01-DQB1*02:01g对T1D易感性的影响取决于DQA1等位基因。DRB1*07:01-DQA1*02:01-DQB1*02:01g对T1D具有保护作用，然而，DQA1*03:01在DRB1*07:01-DQB1*02:01g单倍型上的存在不仅使DR7单倍型不具有保护作用，而且产生了具有显著T1D风险的单倍型。这些数据强调了在种族背景下评估遗传影响的重要性。
To test the hypothesis that closely-related HLA haplotypes containing the DRB1*07:01 gene (“DR7” haplotypes) derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ-α molecule present. A combined total of ninety-eight African American T1D patients from the Type 1 Diabetes Genetics Consortium and from Children’s Hospital and Research Center Oakland were genotyped for the HLA class II loci DRB1, DQA1, and DQB1. DNA samples extracted from newborn blood spot cards from African Americans born in California (n=947) were used as a population-based control group. Among African American cases, the European-derived DRB1*07:01-DQA1*02:01-DQB1*02:01g haplotype was protective for T1D risk (odds ratio (OR)=0.34; 95% CI 0.14 - 0.78; p<0.011), but the African-derived DRB1*07:01-DQA1*03:01-DQB1*02:01g haplotype increased T1D risk (OR=3.96; 95% CI 1.94 - 8.08; p<5.5E-05). The effect of DRB1*07:01-DQB1*02:01g on T1D susceptibility depends on the DQA1 allele. DRB1*07:01-DQA1*02:01-DQB1*02:01g is protective for T1D however, the presence of DQA1*03:01 on the DRB1*07:01-DQB1*02:01g haplotype not only renders the DR7 haplotype not protective, it creates a haplotype with significant T1D risk. These data underscore the importance of assessing genetic effects within ethnic context.
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影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
影响因子：
7.7
作者：
Varney MD;Valdes AM;Carlson JA;Noble JA;Tait BD;Bonella P;Lavant E;Fear AL;Louey A;Moonsamy P;Mychaleckyj JC;Erlich H;Type 1 Diabetes Genetics Consortium
通讯作者：
Type 1 Diabetes Genetics Consortium
DOI：
10.1016/s0950-351x(05)80130-2
发表时间：
1991-06-01
期刊：
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM
影响因子：
--
作者：
MIJOVIC, CH;BARNETT, AH;TODD, JA
通讯作者：
TODD, JA
影响因子：
7.7
作者：
Erlich, Henry;Valdes, Ana Maria;Moonsamy, Priscilla
通讯作者：
Moonsamy, Priscilla
DOI：
10.1016/j.ecl.2010.05.011
发表时间：
2010-09
影响因子：
4.5
作者：
Maahs, David M.;West, Nancy A.;Lawrence, Jean M.;Mayer-Davis, Elizabeth J.
通讯作者：
Mayer-Davis, Elizabeth J.