Inhibition and enhancement of contextual fear memory destabilization.
Inhibition and enhancement of contextual fear memory destabilization.
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DOI：
10.3389/fnbeh.2014.00144
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发表时间：
2014
影响因子：
3
通讯作者：
Flavell CR
中科院分区：
文献类型：
--
作者：
Lee JL;Flavell CR
记忆的重新激活可能会导致其不稳定，需要一个记忆重新巩固的过程来维持其持久性。在这里，我们发现大麻素 CB1 受体激动剂花生四烯基-2-氯乙酰胺 (ACEA) 会加剧情境恐惧记忆的不稳定。将 ACEA 和 IkappaB 激酶 (IKK) 抑制剂柳氮磺吡啶 (Sulf) 共同注入背侧海马会损害情境恐惧记忆的再巩固。这一观察结果是在行为条件下实现的，这些行为条件本身不会导致单独使用 Sulf 导致再巩固损伤。此外，我们发现情境恐惧记忆的不稳定取决于背侧海马的神经元活动，而不是记忆表达本身。通过全身注射复制了海马内 ACEA 对情境恐惧记忆不稳定的影响，从而实现了 MK-801 的遗忘作用。这些结果表明，记忆表达和不稳定虽然彼此独立，但都依赖于记忆重新激活。此外，记忆不稳定可以通过药理学得到增强，这可能具有治疗潜力。
The reactivation of a memory can result in its destabilization, necessitating a process of memory reconsolidation to maintain its persistence. Here we show that the destabilization of a contextual fear memory is potentiated by the cannabinoid CB1 receptor agonist Arachidonyl-2-chloroethylamide (ACEA). Co-infusion of ACEA and the IkappaB kinase (IKK) inhibitor sulfasalazine (Sulf) into the dorsal hippocampus impaired contextual fear memory reconsolidation. This observation was achieved under behavioral conditions that, by themselves, did not result in a reconsolidation impairment by Sulf alone. Moreover, we show that the destabilization of a contextual fear memory is dependent upon neuronal activity in the dorsal hippocampus, but not memory expression per se. The effect on contextual fear memory destabilization of intra-hippocampal ACEA was replicated by systemic injections, allowing an amnestic effect of MK-801. These results indicate that memory expression and destabilization, while being independent from one another, are both dependent upon memory reactivation. Moreover, memory destabilization can be enhanced pharmacologically, which may be of therapeutic potential.
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影响因子：
3.3
作者：
Alvares, L. De Oliveira;Genro, B. Pasqualini;Quillfeldt, J. A.
通讯作者：
Quillfeldt, J. A.
影响因子：
64.8
作者：
Nader, K;Schafe, GE;Le Doux, JE
通讯作者：
Le Doux, JE
影响因子：
2.9
作者：
Lorenzini, CA;Baldi, E;Tassoni, G
通讯作者：
Tassoni, G
影响因子：
2.7
作者：
Barreiro, Karina A.;Suarez, Luis D.;Delorenzi, Alejandro
通讯作者：
Delorenzi, Alejandro
影响因子：
5.6
作者：
Bitencourt, Rafael M.;Pamplona, Fabricio A.;Takahashi, Reinaldo N.
通讯作者：
Takahashi, Reinaldo N.