Reflex voiding in rat occurs at consistent bladder volume regardless of pressure or infusion rate.
Reflex voiding in rat occurs at consistent bladder volume regardless of pressure or infusion rate.
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DOI：
10.1002/nau.25243
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发表时间：
2023-09
影响因子：
2
通讯作者：
Danziger, Zachary C.
中科院分区：
文献类型：
--
作者：
Jaskowak, Daniel J.;Danziger, Zachary C.
中枢神经系统（CNS）利用来自感觉传入的信息调节下尿路反射;然而，该过程的机制尚不清楚。在一系列输注速率下，在监护和排尿反射开始时测量压力和容量，以了解CNS正在测量什么来激活反射。用氨基甲酸乙酯麻醉雌性Sprague道利大鼠，进行开放出口膀胱测压。将一组10种输注速率（范围为0.92-65.5 mL/h）伪随机分布在30张单次充盈膀胱测压图中。膀胱压力和尿道外括约肌肌电图分别用于测定排尿和保护反射的开始。根据单次充盈期间的总输注速率估计两种反射开始时的膀胱体积。在许多单次充盈膀胱测压中，膀胱可以储存的体积增加，而压力没有显著增加。针对该效应调整容量，以分析排尿和保护反射开始时压力和容量如何随输注速率变化。在25只大鼠中，在所有输注速率下以相似的体积诱发排尿反射，而排尿反射开始时的压力随着输注速率的增加而增加。在11只大鼠中，在不同输注速率的相似压力下诱发了守卫反射，但体积随着输注速率的增加而减小。这些结果表明，中枢神经系统正在解释来自膀胱的容量以激活排尿反射，并解释来自膀胱的压力以激活保护反射。
The central nervous system (CNS) regulates lower urinary tract reflexes using information from sensory afferents; however, the mechanisms of this process are not well known. Pressure and volume were measured at the onset of the guarding and micturition reflexes across a range of infusion rates to provide insight into what the CNS is gauging to activate reflexes. Female Sprague Dawley rats were anesthetized with urethane for open outlet cystometry. A set of 10 infusion rates (ranging 0.92–65.5 mL/h) were pseudo-randomly distributed across 30 single-fill cystometrograms. Bladder pressure and external urethral sphincter electromyography were used for the determination of the onset of the micturition and guarding reflexes, respectively. The bladder volume at the onset of both reflexes was estimated from the total infusion rate during a single fill. In response to many single-fill cystometrograms, there was an increased volume the bladder could store without a significant increase in pressure. Volume was adjusted for this effect for the analysis of how pressure and volume varied with infusion rate at the onset of the micturition and guarding reflexes. In 25 rats, the micturition reflex was evoked at similar volumes across all infusion rates, whereas the pressure at micturition reflex onset increased with increasing infusion rates. In 11 rats, the guarding reflex was evoked at similar pressures across infusion rates, but the volume decreased with increasing infusion rates. These results suggest that the CNS is interpreting volume from the bladder to activate the micturition reflex and pressure from the bladder to activate the guarding reflex.
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膀胱中尿路上皮感觉系统中的受体，通道和信号传导。
DOI：
10.1038/nrurol.2016.13
发表时间：
2016-04
期刊：
Nature reviews. Urology
影响因子：
--
作者：
Merrill L;Gonzalez EJ;Girard BM;Vizzard MA
通讯作者：
Vizzard MA
影响因子：
2
作者：
Gupta, A;Defreitas, G;Lemack, GE
通讯作者：
Lemack, GE
DOI：
10.1111/j.1475-097x.1989.tb00959.x
发表时间：
1989-02-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
ANDERSSON, S;BJERLE, P;NIKLASSON, U
通讯作者：
NIKLASSON, U
影响因子：
5.3
作者：
BRADLEY, WE;TEAGUE, CT
通讯作者：
TEAGUE, CT
影响因子：
2
作者：
Brostrom, S;Jennum, P;Lose, G
通讯作者：
Lose, G