A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
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A-to-I RNA 编辑有助于癌症蛋白质组多样性
DOI：
10.1016/j.ccell.2018.03.026
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发表时间：
2018-05-14
期刊：
影响因子：
50.3
通讯作者：
Mills GB
中科院分区：
文献类型：
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作者：
Peng X;Xu X;Wang Y;Hawke DH;Yu S;Han L;Zhou Z;Mojumdar K;Jeong KJ;Labrie M;Tsang YH;Zhang M;Lu Y;Hwu P;Scott KL;Liang H;Mills GB
Adenosine (A) to inosine (I) RNA editing introduces many nucleotide changes in cancer transcriptomes. However, due to the complexity of posttranscriptional regulation, the contribution of RNA editing to proteomic diversity in human cancers remains unclear. Here we performed an integrated analysis of TCGA genomic data and CPTAC proteomic data. Despite of limited site diversity, we demonstrate that A-to-I RNA editing contributes to proteomic diversity in breast cancer through changes in amino acid sequences. We validate the presence of editing events at both RNA and protein levels. The edited COPA protein increases proliferation, migration, and invasion of cancer cells in vitro. Our study suggests an important contribution of A-to-I RNA editing to protein diversity in cancer and highlights its translational potential. By an integrated analysis of TCGA genomic data and CPTAC proteomic data, Peng et al. show that A-to-I RNA editing contributes to proteomic diversity in breast cancer through changes in amino acid sequences. The edited COPA protein increases proliferation, migration, and invasion of cancer cells in vitro.
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影响因子：
7.4
作者：
Crews LA;Jiang Q;Zipeto MA;Lazzari E;Court AC;Ali S;Barrett CL;Frazer KA;Jamieson CH
通讯作者：
Jamieson CH
人蛋白质组项目质谱数据解释指南2.1。
影响因子：
4.4
作者：
Deutsch EW;Overall CM;Van Eyk JE;Baker MS;Paik YK;Weintraub ST;Lane L;Martens L;Vandenbrouck Y;Kusebauch U;Hancock WS;Hermjakob H;Aebersold R;Moritz RL;Omenn GS
通讯作者：
Omenn GS
影响因子：
15.3
作者：
Han, Sae-Won;Kim, Hwang-Phill;Kim, Tae-You
通讯作者：
Kim, Tae-You
I-Mutant2.0：预测蛋白质序列或结构突变的稳定性变化。
影响因子：
14.9
作者：
Capriotti, E;Fariselli, P;Casadio, R
通讯作者：
Casadio, R
AZIN1 的重新编码 RNA 编辑易诱发肝细胞癌。
影响因子：
82.9
作者：
通讯作者：
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