Cellular and systemic energy metabolic dysregulation in asthma development-a hypothesis-generating approach.
Cellular and systemic energy metabolic dysregulation in asthma development-a hypothesis-generating approach.
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哮喘发育中的细胞和全身能量代谢失调 - 假设生成方法。
DOI：
10.1016/j.jaci.2021.10.024
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发表时间：
2022-05
影响因子：
14.2
通讯作者：
Hartert, Tina, V
中科院分区：
文献类型：
--
作者：
Berdnikovs, Sergejs;Newcomb, Dawn C.;Gebretsadik, Tebeb;Snyder, Brittney M.;Wiggins, Derek A.;Poleon, Kadijah S.;Hartert, Tina, V
系统性和气道特异性上皮能量代谢在改变生命早期气道上皮细胞（AEC）发育程序中的作用知之甚少。评估有和无喘息的儿童中发生AEC的碳水化合物代谢，并检测婴儿血浆能量生物标志物与随后复发性喘息和哮喘结局的相关性。我们测量了从15名有和没有喘息史的男性受试者中收集的2岁时的活鼻AEC中的细胞碳水化合物代谢，并进行了主成分分析，以直观地评估关于糖酵解代谢物和单糖的AEC代谢的数据聚类。在237名有1年血浆样本的儿童中，我们使用广义估计方程和逻辑回归来检验1年血浆能量生物标志物与复发性喘鸣和哮喘的关系。有喘鸣病史的儿童对鼻AEC中葡萄糖的利用率低于无喘鸣病史的儿童。从全身来看，第1年血糖浓度较高（在正常范围内）与5岁至5岁时哮喘发生率降低相关（校正比值比[aOR] 0.56，95%置信区间[CI] 0.35-0.90）。第1年的胰岛素、葡萄糖/胰岛素比值、c-肽和瘦素与2-5岁的喘息复发相关。这些研究表明，在生命早期存在显著的能量代谢失调，这可能影响AEC的发展。婴儿期上皮细胞代谢的这些紊乱可能对肺发育产生持久影响，这可能使气道更容易受到过敏性致敏作用的影响。这些研究表明，在生命早期存在显著的能量代谢失调，这可能影响气道上皮细胞的发育。
The roles of systemic and airway-specific epithelial energy metabolism in altering the developmental programming of airway epithelial cells (AECs) in early life are poorly understood. To assess carbohydrate metabolism in developing AECs among children with and without wheeze and test the association of infant plasma energy biomarkers with subsequent recurrent wheeze and asthma outcomes. We measured cellular carbohydrate metabolism in live nasal AECs collected at age 2-years from 15 male subjects with and without wheeze history and performed a principal component analysis to visually assess clustering of data on AEC metabolism of glycolitic metabolites and simple sugars. Among 237 children with available 1-year plasma samples, we tested the associations of 1-year plasma energy biomarkers and recurrent wheeze and asthma using generalized estimating equations and logistic regression. Children with a history of wheeze had lower utilization of glucose in nasal AECs than children with no wheeze. Systemically, higher plasma glucose concentration at year 1 (within the normal range) was associated with decreased odds of asthma at age 5-years (adjusted odds ratio [aOR] 0.56, 95% confidence interval [CI] 0.35–0.90). Insulin, glucose/insulin ratio, c-peptide, and leptin at year 1 were associated with recurrent wheeze from age 2–5 years. These studies suggest that there is significant energy metabolism dysregulation in early life which likely impacts AEC development. These pertubations of epithelial cell metabolism in infancy may have lasting effects on lung development, which could render the airway more susceptible to allergic sensitization. These studies suggest that there is significant energy metabolism dysregulation in early life which likely impacts airway epithelial cell development.
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影响因子：
3.7
作者：
Savino F;Rossi L;Benetti S;Petrucci E;Sorrenti M;Silvestro L
通讯作者：
Silvestro L
DOI：
10.1016/j.jaci.2017.04.010
发表时间：
2017-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Schleimer RP;Berdnikovs S
通讯作者：
Berdnikovs S
影响因子：
3.6
作者：
DeChristopher, Luanne R.;Tucker, Katherine L.
通讯作者：
Tucker, Katherine L.
影响因子：
15.9
作者：
Xu, Weiling;Ghosh, Sudakshina;Erzurum, Serpil C.
通讯作者：
Erzurum, Serpil C.
影响因子：
3.7
作者：
Percopo CM;McCullough M;Limkar AR;Druey KM;Rosenberg HF
通讯作者：
Rosenberg HF