Neural dynamics of verbal working memory in auditory description naming.
Neural dynamics of verbal working memory in auditory description naming.
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DOI：
10.1038/s41598-018-33776-2
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发表时间：
2018-10-26
影响因子：
4.6
通讯作者：
Asano E
中科院分区：
文献类型：
--
作者：
Kambara T;Brown EC;Silverstein BH;Nakai Y;Asano E
听觉命名除了在听句阶段的语音感知和随后的判断阶段的语义/句法处理外，还需要言语工作记忆(WM)操作。我们试图从回答听觉句子问题的大脑皮质中分离出可归因于言语工作记忆的皮层激活。我们研究了19名患者，他们接受了皮层脑电记录，并在听觉命名和WM任务中测量了高伽马活动。在听觉命名任务中，在听句子的过程中，下中央前高伽马活动增强，并且增强的幅度与西医任务维持期和患者的年龄独立相关。WM任务扫描期间的高伽马增强可解释命名任务判断期间部分左额联合新皮质区域的高伽马变化(最显著的是中额叶，次之是额下区，最小的是眶前回)。在命名任务判断中，下额叶高伽马增强以左半球为主，而在WM扫描中表现为对称性。左眶前额高伽马增强仅在命名任务判断阶段明显，而在WM任务扫描阶段微乎其微。在听句子的过程中，中央前下区可能会产生WM维持功能，随着大脑的成熟，这种维持功能可能会逐渐增强。在命名任务判断过程中，左额叶联系新皮质的功能角色可能具有背侧到腹侧的梯度。也就是说，左中额叶激活可能主要归因于WM扫描功能，而左眶前额叶激活可能较少归因于WM扫描，而更多地归因于句法/语义加工。
Auditory naming is suggested to require verbal working memory (WM) operations in addition to speech sound perception during the sentence listening period and semantic/syntactic processing during the subsequent judgement period. We attempted to dissect cortical activations attributable to verbal WM from those otherwise involved in answering auditory sentence questions. We studied 19 patients who underwent electrocorticography recordings and measured high-gamma activity during auditory naming and WM tasks. In the auditory naming task, inferior-precentral high-gamma activity was augmented during sentence listening, and the magnitude of augmentation was independently correlated to that during the WM task maintenance period as well as patient age. High-gamma augmentation during the WM task scanning period accounted for high-gamma variance during the naming task judgement period in some of the left frontal association neocortex regions (most significantly in the middle-frontal, less in the inferior-frontal, and least in the orbitofrontal gyrus). Inferior-frontal high-gamma augmentation was left-hemispheric dominant during naming task judgement but rather symmetric during WM scanning. Left orbitofrontal high-gamma augmentation was evident only during the naming task judgement period but minimal during the WM task scanning period. The inferior-precentral regions may exert WM maintenance during sentence listening, and such maintenance function may be gradually strengthened as the brain matures. The left frontal association neocortex may have a dorsal-to-ventral gradient in functional roles during naming task judgement. Namely, left middle-frontal activation may be well-attributable to WM scanning function, whereas left orbitofrontal activation may be attributable less to WM scanning but more largely to syntactic/semantic processing.
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影响因子：
16.2
作者：
Dapretto, M;Bookheimer, SY
通讯作者：
Bookheimer, SY
DOI：
10.1073/pnas.95.3.906
发表时间：
1998-02-03
影响因子：
11.1
作者：
Gabrieli, JDE;Poldrack, RA;Desmond, JE
通讯作者：
Desmond, JE
DOI：
10.1073/pnas.1612132113
发表时间：
2016-10-11
影响因子：
11.1
作者：
Fedorenko, Evelina;Scott, Terri L.;Kanwisher, Nancy
通讯作者：
Kanwisher, Nancy
影响因子：
7.7
作者：
Cheung, Connie;Hamiton, Liberty S.;Chang, Edward F.
通讯作者：
Chang, Edward F.
影响因子：
4.8
作者：
Brown, Erik C.;Jeong, Jeong-Won;Muzik, Otto;Rothermel, Robert;Matsuzaki, Naoyuki;Juhasz, Csaba;Sood, Sandeep;Asano, Eishi
通讯作者：
Asano, Eishi