Evaluating the arcuate fasciculus with combined diffusion-weighted MRI tractography and electrocorticography.
Evaluating the arcuate fasciculus with combined diffusion-weighted MRI tractography and electrocorticography.
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DOI：
10.1002/hbm.22331
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Asano, Eishi
中科院分区：
文献类型：
--
作者：
Brown, Erik C.;Jeong, Jeong-Won;Muzik, Otto;Rothermel, Robert;Matsuzaki, Naoyuki;Juhasz, Csaba;Sood, Sandeep;Asano, Eishi
关键词：
语言相关脑结构的传统模型将弓状束描述为一个关键的白色物质束，提供了韦尼克区和布罗卡区之间的直接联系，这一模型受到了质疑。具体而言，下中央前回，拥有初级运动（布罗德曼区[BA] 4）和运动前皮层（BA 6），已被确定为一个潜在的替代终止。作者最初使用皮层电图（ECoG）上的事件相关γ活动测量来定位涉及语言的皮层部位。然后，作者确定了颞叶的语言相关部位是否通过白色物质结构与额下回的连接比与中央前回的连接更紧密。作者发现，颞叶的语言相关部位更有可能通过弓状束直接连接到中央前回。此外，纤维束描记术是一个重要的预测额叶语言相关的皮层脑电图结果。在这个模型中，解剖学和纤维束成像之间的相互作用的分析显示，纤维束成像对中央前回的语言相关ECoG结果具有最高的预测价值。这项研究未能支持语言相关的大脑结构的传统模型。更可行的模型应该包括下中央前回作为弓状束的终止。颞叶语言相关部位与中央前回直接连接的确切功能意义有待进一步研究。
The conventional model of language-related brain structure describing the arcuate fasciculus as a key white matter tract providing a direct connection between Wernicke’s region and Broca’s area has been called into question. Specifically, the inferior precentral gyrus, possessing both primary motor (Brodmann Area [BA] 4) and premotor cortex (BA 6), has been identified as a potential alternative termination. The authors initially localized cortical sites involved in language using measurement of event-related gamma-activity on electrocorticography (ECoG). The authors then determined whether language-related sites of the temporal lobe were connected, via white matter structures, to the inferior frontal gyrus more tightly than to the precentral gyrus. The authors found that language-related sites of the temporal lobe were far more likely to be directly connected to the inferior precentral gyrus through the arcuate fasciculus. Furthermore, tractography was a significant predictor of frontal language-related ECoG findings. Analysis of an interaction between anatomy and tractography in this model revealed tractrography to have the highest predictive value for language-related ECoG findings of the precentral gyrus. This study failed to support the conventional model of language-related brain structure. More feasible models should include the inferior precentral gyrus as a termination of the arcuate fasciculus. The exact functional significance of direct connectivity between temporal language-related sites and the precentral gyrus requires further study.
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影响因子：
5.7
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
1976-01-01
影响因子：
5.2
作者：
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通讯作者：
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影响因子：
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