Early life seizures cause long-standing impairment of the hippocampal map.
Early life seizures cause long-standing impairment of the hippocampal map.
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DOI：
10.1016/j.expneurol.2009.03.028
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发表时间：
2009-06
影响因子：
5.3
通讯作者：
Holmes, Gregory L.
中科院分区：
文献类型：
--
作者：
Karnam, Havisha B.;Zhou, Jun-Li;Huang, Li-Tung;Zhao, Qian;Shatskikh, Tatiana;Holmes, Gregory L.
关键词：
癫痫发作的儿童有长期认知缺陷的风险。同样，发育中的大鼠的反复发作与空间学习和记忆的缺陷有关。然而，这些缺陷的病理生理基础尚不清楚。海马体位置细胞，当动物在空间中移动到特定位置时被选择性激活的细胞，为动物提供了空间地图。我们假设癫痫引起的空间学习障碍是大鼠无法形成准确和稳定的海马体地图的结果。为了直接解决空间记忆障碍的细胞伴随物，我们记录了自由运动大鼠在出生后的第一周内遭受100次氟化氟诱发的短暂癫痫发作的海马CA1亚区位置细胞的活动，然后在莫里斯水迷宫和放射状臂水迷宫中进行了位置细胞测试。与对照组相比，反复发作大鼠Morris水迷宫和桡臂水迷宫功能明显受损。与此同时，位置细胞的动作电位放电特征也存在明显缺陷，主要表现在两个方面：1)与对照细胞相比，位置细胞的相干性、信息含量、中心放电速率和场大小都有所降低；(2)与对照位置细胞相比，磁场的稳定性较差。这些结果表明，发育早期的反复发作与空间学习的显著损伤有关，并且这些缺陷与海马体图的缺陷是平行的。因此，这项研究为早期发育期间反复发作如何导致认知障碍提供了细胞相关性。
Children with seizures are at risk for long-term cognitive deficits. Similarly, recurrent seizures in developing rats are associated with deficits in spatial learning and memory. However, the pathophysiological bases for these deficits are not known. Hippocampal place cells, cells that are activated selectively when an animal moves through a particular location in space, provides the animal with a spatial map. We hypothesized that seizure-induced impairment in spatial learning is a consequence of the rat’s inability to form accurate and stable hippocampal maps. To directly address the cellular concomitants of spatial memory impairment, we recorded the activity of place cells from hippocampal subfield CA1 in freely moving rats subjected to 100 brief flurothyl-induced seizures during the first weeks of life and then tested them in the Morris water maze and radial-arm water maze followed by place cell testing. Compared to controls, rats with recurrent seizures had marked impairment in Morris water maze and radial-arm water maze. In parallel, there were substantial deficits in action potential firing characteristics of place cells with two major defects: i) the coherence, information content, center firing rate, and field size were reduced compared to control cells; and ii) the fields were less stable than those in control place cells. These results show that recurrent seizures during early development are associated with significant impairment in spatial learning and that these deficits are paralleled by deficits in the hippocampal map. This study thus provides a cellular correlate for how recurrent seizures during early development lead to cognitive impairment.
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影响因子：
5.6
作者：
Bailet, LL;Turk, WR
通讯作者：
Turk, WR
影响因子：
3
作者：
Bjornæs, H;Stabell, K;Loyning, Y
通讯作者：
Loyning, Y
影响因子：
2.7
作者：
French, KL;Granholm, ACE;Bimonte-Nelson, HA
通讯作者：
Bimonte-Nelson, HA
影响因子：
11.2
作者：
Holmes, GL;Gairsa, JL;Ben-Ari, Y
通讯作者：
Ben-Ari, Y
DOI：
10.1016/s0165-3806(99)00135-2
发表时间：
1999-12-10
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Huang, LT;Cilio, MR;Holmes, GL
通讯作者：
Holmes, GL