Disseminated Tuberculosis With an Atypical Cutaneous Manifestation in a Hematopoietic Cell Transplant Patient in the Early Posttransplant Period: Case Report and Review of the Literature.
Disseminated Tuberculosis With an Atypical Cutaneous Manifestation in a Hematopoietic Cell Transplant Patient in the Early Posttransplant Period: Case Report and Review of the Literature.
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DOI：
10.1093/ofid/ofac643
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发表时间：
2022-12
影响因子：
4.2
通讯作者：
中科院分区：
文献类型：
--
作者：
我们描述了一个不寻常的情况下，移植后结核病复发的男子谁接受异基因造血细胞移植。伴随播散性腺病毒感染，结核病再活化表现为第+49天的播散性非滤泡性脓疱。在第+50天获得皮肤活检。最初的组织病理学评价未提示分枝杆菌感染，但组织染色显示抗酸微生物，随后确定为结核分枝杆菌。在皮肤结核表现后不久，患者于第+52天死亡。我们的病例是描述造血细胞移植患者在移植后早期结核病复发的少数报道之一。它突出了诊断同期全身感染的困难，它提出了一种罕见的和非典型的皮肤表现的结核病在造血细胞移植患者。我们的病例和文献回顾强调需要进一步的研究来阐明与移植后早期结核病再激活相关的危险因素，以及在有流行病学危险因素的造血细胞移植患者中对活动性结核病保持警惕的重要性。
We describe an unusual case of posttransplant tuberculosis reactivation in a man who underwent allogeneic hematopoietic cell transplant. Concomitant with disseminated adenovirus infection, reactivation of tuberculosis manifested as disseminated, nonfollicular pustules on day +49. Skin biopsy was obtained on day +50. Initial histopathologic evaluation did not suggest mycobacterial infection, but tissue stain showed acid-fast organisms, which were subsequently identified as Mycobacterium tuberculosis. Shortly after the cutaneous presentation of tuberculosis, the patient died on day +52. Our case is among a paucity of reports describing tuberculosis reactivation in hematopoietic cell transplant patients in the early posttransplant period. It highlights the difficulty of diagnosing contemporaneous systemic infections, and it presents a rare and atypical cutaneous manifestation of tuberculosis in a hematopoietic cell transplant patient. Our case and review of the literature emphasize the need for further research to elucidate risk factors associated with early posttransplant reactivation of tuberculosis, and the importance of remaining vigilant for active tuberculosis in hematopoietic cell transplant patients with epidemiologic risk factors.
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作者：
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通讯作者：
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