Pathogenesis of Relapsing Fever.
Pathogenesis of Relapsing Fever.
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DOI：
10.21775/cimb.042.519
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发表时间：
2021
影响因子：
3.1
通讯作者：
Bergström S
中科院分区：
文献类型：
--
作者：
Lopez J;Hovius JW;Bergström S
复发性热(RF)是由几种疏螺旋体引起的；除了两种之外，所有的都是通过软的(扁虱)传播给人类的。重复性B.rentis通过体虱从一个人传播到另一个人，而B.miyamotoi是由硬体硬蜱传播的。RF疏螺旋体具有几个致病特征，便于在受感染宿主中入侵和传播。在这篇文章中，我们讨论了介体获取和随后传播给脊椎动物宿主的动力学。我们还回顾了RF疏螺旋体面临的分类学挑战，因为全球已分离出新物种。并对其发病机制，包括症状、神经功能、红细胞和血小板黏附等方面进行了讨论。阐述了疏螺旋体先天免疫和获得性免疫的逃逸策略，重点阐述了疏螺旋体的最基本致病属性，即多相抗原变异。最后，我们回顾了新出现的疏螺旋体新种，并讨论了这种全球疾病的未来发展方向。
Relapsing fever (RF) is caused by several species of Borrelia; all, except two species, are transmitted to humans by soft (argasid) ticks. The species B. recurrentis is transmitted from one human to another by the body louse, while B. miyamotoi is vectored by hard-bodied ixodid tick species. RF Borrelia have several pathogenic features that facilitate invasion and dissemination in the infected host. In this article we discuss the dynamics of vector acquisition and subsequent transmission of RF Borrelia to their vertebrate hosts. We also review taxonomic challenges for RF Borrelia as new species have been isolated throughout the globe. Moreover, aspects of pathogenesis including symptomology, neurotropism, erythrocyte and platelet adhesion are discussed. We expound on RF Borrelia evasion strategies for innate and adaptive immunity, focusing on the most fundamental pathogenetic attributes, multiphasic antigenic variation. Lastly, we review new and emerging species of RF Borrelia and discuss future directions for this global disease.
螺旋藻复发的复发现象。
影响因子：
15.3
作者：
Meleney, HE
通讯作者：
Meleney, HE
DOI：
10.1084/jem.158.6.2127
发表时间：
1983-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barbour AG;Barrera O;Judd RC
通讯作者：
Judd RC
影响因子：
3.7
作者：
Vidal V;Cutler S;Scragg IG;Wright DJ;Kwiatkowski D
通讯作者：
Kwiatkowski D