Defective efferocytosis by alveolar macrophages in IPF patients.
Defective efferocytosis by alveolar macrophages in IPF patients.
复制标题
DOI：
10.1016/j.rmed.2012.08.020
复制
发表时间：
2012-12
影响因子：
4.3
通讯作者：
Terada, Mayumi
中科院分区：
文献类型：
--
作者：
Morimoto, Konosuke;Janssen, William J.;Terada, Mayumi
特发性肺纤维化（IPF）是一种慢性、进行性纤维化间质性肺炎。IPF的致病性已被广泛研究，但仍有待澄清。胞吐作用是吞噬细胞对凋亡细胞的专门识别和摄取，对于肺部炎症的消退和受损组织的修复至关重要。受损的红细胞增多症有助于慢性肺部疾病如肺气肿和囊性纤维化的发病机制。我们假设从IPF受试者中分离出的肺泡巨噬细胞中的细胞发热作用也会减少。使用从IPF（n = 5）、非特异性间质性肺炎（n = 6）、隐源性机化性肺炎（n = 4）和嗜酸性粒细胞性肺炎（EP）（n = 5）患者的支气管肺泡灌洗液（BAL）中分离的瑞氏-姬姆萨染色细胞制剂评价了胞饮作用。与其他形式的间质性肺病相比，IPF患者的BAL液中未摄入的凋亡细胞显著较高。从嗜酸性粒细胞性肺炎患者中分离的巨噬细胞的吞噬能力明显低于其他三组的巨噬细胞。IPF受试者中肺泡巨噬细胞的胞饮作用显著低于其他间质性肺炎受试者。异常调节的红细胞增多可能促成IPF的发病机制。
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of inflammation in the lungs and repair of injured tissues. Impaired efferocytosis contributes to the pathogenesis of chronic lung diseases such as emphysema and cystic fibrosis. We hypothesized that efferocytosis would also be reduced in alveolar macrophages isolated from subjects with IPF. Efferocytosis, was evaluated using Wright-Giemsa stained cell preparations isolated from the bronchoalveolar lavage (BAL) fluid of patients with IPF (n = 5), nonspecific interstitial pneumonitis (n = 6), cryptogenic organizing pneumonia (n = 4) and eosinophilic pneumonia (EP) (n = 5). Uningested apoptotic cells were significantly higher in BAL fluid from patients with IPF compared to other forms of interstitial lung disease. Macrophages isolated from patients with eosinophilic pneumonia had significantly fewer phagocytic ingestions than macrophages from the other three groups. Efferocytosis by alveolar macrophages was significantly lower in subjects with IPF compared to subjects with other interstitial pneumonia. Dysregulated efferocytosis may contribute to the pathogenesis of IPF.
登录
查看更多内容
影响因子：
3.7
作者：
Murray LA;Rosada R;Moreira AP;Joshi A;Kramer MS;Hesson DP;Argentieri RL;Mathai S;Gulati M;Herzog EL;Hogaboam CM
通讯作者：
Hogaboam CM
DOI：
10.1164/rccm.200509-1518oc
发表时间：
2006-04-01
影响因子：
24.7
作者：
Prasse, A;Pechkovsky, DV;Zissel, G
通讯作者：
Zissel, G
影响因子：
15.9
作者：
Vandivier, RW;Fadok, VA;Henson, PM
通讯作者：
Henson, PM
影响因子：
9.6
作者：
Vandivier, R. William;Henson, Peter M.;Douglas, Ivor S.
通讯作者：
Douglas, Ivor S.
DOI：
10.1016/j.biocel.2008.02.016
发表时间：
2008-01-01
影响因子：
4
作者：
Murray, Lynne A.;Argentieri, Rochelle L.;Das, Anuk M.
通讯作者：
Das, Anuk M.