Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.
Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.
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DOI：
10.2741/3875
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Gorski JP
中科院分区：
文献类型：
--
作者：
Gorski JP
The impact of genetics has dramatically affected our understanding of the functions of non-collagenous proteins. Specifically, mutations and knockouts have defined their cellular spectrum of actions. However, the biochemical mechanisms mediated by non-collagenous proteins in biomineralization remain elusive. It is likely that this understanding will require more focused functional testing at the protein, cell, and tissue level. Although initially viewed as rather redundant and static acidic calcium binding proteins, it is now clear that non-collagenous proteins in mineralizing tissues represent diverse entities capable of forming multiple protein-protein nteractions which act in positive and negative ways to regulate the process of bone mineralization. Several new examples from the author’s laboratory are provided which illustrate this theme including an apparent activating effect of hydroxyapatite crystals on metalloproteinases. This review emphasizes the view that secreted non-collagenous proteins in mineralizing bone actively participate in the mineralization process and ultimately control where and how much mineral crystal is deposited, as well as determining the quality and biomechanical properties of the mineralized matrix produced.
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影响因子：
4.8
作者：
Cheung, HS;Kurup, IV;Ryan, LM
通讯作者：
Ryan, LM
DOI：
10.1083/jcb.35.1.81
发表时间：
1967-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson HC
通讯作者：
Anderson HC
影响因子：
6.9
作者：
Al-Jallad, HF;Nakano, Y;Kaartinen, MT
通讯作者：
Kaartinen, MT
DOI：
10.1111/j.1749-6632.1995.tb44635.x
发表时间：
1995-01-01
期刊：
OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION
影响因子：
--
作者：
BOSKEY, AL
通讯作者：
BOSKEY, AL
DOI：
10.1016/0169-6009(92)90740-5
发表时间：
1992-05-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
BONUCCI, E
通讯作者：
BONUCCI, E