Pericyte infection by HIV-1: a fatal attraction.
Pericyte infection by HIV-1: a fatal attraction.
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DOI：
10.1186/s12977-022-00614-3
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发表时间：
2022-12-07
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然HIV-1主要是CD4 + T细胞的感染，但人们对了解其他细胞类型的感染如何导致hiv相关合并症的兴趣正在增加。HIV-1要从血流进入组织，病毒必须直接接触血管内皮，包括包住血管内皮细胞的周细胞。周细胞是一种多功能细胞，在血管生成、血管维持和血流速率中发挥着重要作用。最重要的是，最近的证据表明，周细胞可以成为HIV-1感染的靶点，并支持病毒生命周期的活跃阶段，体外数据也表明存在潜伏期。HIV-1的周细胞感染已在死后的人类大脑和siv感染的猕猴的肺部得到证实。此外，周细胞功能障碍涉及多种病理，从缺血性中风到糖尿病，这些都是HIV-1感染者常见的合并症。在这篇综述中，我们讨论了周细胞在HIV-1感染中的作用及其对hiv相关合并症进展的贡献。
While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the vascular endothelium, including pericytes that envelope vascular endothelial cells. Pericytes are multifunctional cells that have been recognized for their essential role in angiogenesis, vessel maintenance, and blood flow rate. Most importantly, recent evidence has shown that pericytes can be a target of HIV-1 infection and support an active stage of the viral life cycle, with latency also suggested by in vitro data. Pericyte infection by HIV-1 has been confirmed in the postmortem human brains and in lungs from SIV-infected macaques. Moreover, pericyte dysfunction has been implicated in a variety of pathologies ranging from ischemic stroke to diabetes, which are common comorbidities among people with HIV-1. In this review, we discuss the role of pericytes during HIV-1 infection and their contribution to the progression of HIV-associated comorbidities.
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影响因子：
3.7
作者：
Bonnet F;Le Marec F;Leleux O;Gerard Y;Neau D;Lazaro E;Duffau P;Caubet O;Vandenhende MA;Mercie P;Cazanave C;Dabis F
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影响因子：
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