Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.
Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.
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DOI:
10.3390/ijms140713391
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发表时间:
2013-06-27
影响因子:
5.6
通讯作者:
Adam V
中科院分区:
文献类型:
--
作者:
Blazkova I;Nguyen HV;Dostalova S;Kopel P;Stanisavljevic M;Vaculovicova M;Stiborova M;Eckschlager T;Kizek R;Adam V
Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
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