A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals

A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals
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羟基磷灰石纳米晶可调掺杂的合成后离子交换方法

DOI:
10.1039/c7ra10516a
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发表时间:
2017-12
期刊:
影响因子:
3.9
通讯作者:
Daidi Fan
Daidi Fan
中科院分区:
化学3区
文献类型:
--
作者:
Gaoyu Chen;Xiaoyan Zheng;Chong Wang;Junfeng Hui;Xuexi Sheng;Xiangxing Xu;Jianchun Bao;Weijun Xiu;Lihui Yuwen;Daidi Fan

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羟基磷灰石(HAp)是人体骨骼和牙齿的主要无机成分。羟基磷酰胺纳米晶体的掺杂在组织工程、药物传递、生物标志物和人工骨等领域发挥着重要作用。本文研究了在有机溶液中掺杂羟基磷灰石(HAp)纳米晶体的合成后金属离子交换方法。它可以是单离子或多离子掺杂Mg2+, Sr2+, Zn2+, Mn2+, Fe3+或Cu2+等,尽管Ca2+和掺杂离子的半径变化较大。掺杂比可以在很宽的范围内调整,例如Fe3+在0-20%之间,这比在水溶液中进行的离子交换要高得多。合成后掺杂的HAp纳米晶体的结构和形态得以保留,具有潜在的生物学应用前景。
Hydroxyapatite (HAp) is the main inorganic component of human bones and teeth. The doping of HAp nanocrystals plays an important role in tissue engineering, drug delivery, biomarkers and artificial bones. In this article, a postsynthetic metal ion exchange method was developed for doping hydroxyapatite (HAp) nanocrystals in organic solutions. It can be mono- or multi-ion doped with Mg2+, Sr2+, Zn2+, Mn2+, Fe3+ or Cu2+ etc., despite the significant radius variation of Ca2+ and doping ions. The doping ratio can be tuned in a wide range, e.g. Fe3+ of 0–20%, which is much higher than the ion exchange performed in aqueous solution. The structure and morphology of the HAp nanocrystals were preserved after postsynthetic doping, suggesting potential biological applications.
羟基磷灰石纳米晶体:胶体化学、组装及其生物应用
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