trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells.
trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells.
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DOI：
10.1016/j.jnutbio.2012.03.017
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Park Y
中科院分区：
文献类型：
--
作者：
Kim J;Park Y;Lee SH;Park Y
骨经过成骨细胞骨形成和骨细胞骨吸收的持续重建以维持适当的骨量。据报道，骨髓肥胖在成骨细胞中具有相互作用，因为它们同样来源于间充质干细胞。此外，脂肪生成的关键介质之一过氧化物酶体增殖物激活受体-γ（PPARγ）在骨髓间充质干细胞的成骨细胞生成中起重要作用。已知对肥胖和骨量有显著影响的一种饮食成分是共轭亚油酸（CLA）。然而，控制肥胖与通过CLA改善骨量之间的联系尚未得到深入研究。因此，本研究的目的是确定共轭亚油酸对骨髓肥胖和骨形成的作用，使用小鼠间充质干细胞。结果证实，反式-10，顺式-12共轭亚油酸，而不是顺式-9，反式-11共轭亚油酸异构体，显着抑制脂肪生成和促进成骨细胞从间充质干细胞。反式-10，cis-12共轭亚油酸对成骨细胞成脂的抑制作用是通过PPARγ介导的，而反式-10，cis-12共轭亚油酸对成骨细胞成脂的抑制作用是直接的，与PPARγ无关。反式-10，顺式-12共轭亚油酸对破骨细胞生成抑制因子（OCIF）也有显著影响，提示共轭亚油酸对破骨细胞生成有潜在影响。总体而言，结果表明，反式-10，顺式-12，而不是顺式-9，反式-11 CLA异构体，通过间充质干细胞中的PPARγ介导和独立机制对骨健康具有积极影响。
Bone undergoes continuous remodeling of osteoblastic bone formation and osteoclastic bone resorption to maintain proper bone mass. It is also reported that bone marrow adiposity has a reciprocal role in osteoblasts due to their same origin from mesenchymal stem cells. In addition, one of the key mediators of adipogenesis, peroxisome-proliferator activated receptor-γ (PPARγ), plays a significant role in osteoblastogenesis in bone marrow mesenchymal stem cells. One dietary component that is known to have significant impact on adiposity and bone mass is conjugated linoleic acid (CLA). However, the link between controlling adiposity to improving bone mass by CLA has not been studied intensively. Thus the purpose of this study is to determine the role of CLA on bone marrow adiposity and bone formation using murine mesenchymal stem cells. The results confirmed that the trans-10,cis-12 CLA, but not the cis-9,trans-11 CLA isomer, significantly inhibited adipogenesis and promoted osteoblastogenesis from mesenchymal stem cells. The inhibition of adipogenesis by the trans-10,cis-12 CLA was mediated by PPARγ, however, the trans-10,cis-12 CLA had direct effect on osteoblastogenesis which was independent to PPARγ in this model. The trans-10,cis-12 CLA also had significant effects on osteoclastogenesis inhibitory factor (OCIF), which suggests potential influence of CLA on osteoclastogenesis. Overall the results suggest that the trans-10,cis-12, but not the cis-9,trans-11 CLA isomer, has positive impact on bone health by both PPARγ mediated and independent mechanisms in mesenchymal stem cells.
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影响因子：
2.9
作者：
Ip, C;Dong, Y;Saebo, A
通讯作者：
Saebo, A
影响因子：
2.7
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1080/07315724.2005.10719463
发表时间：
2005-06-01
影响因子：
3.5
作者：
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通讯作者：
Ilich, JZ
影响因子：
3
作者：
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通讯作者：
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