Phage phiKZ-The First of Giants.

Phage phiKZ-The First of Giants.
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DOI:
10.3390/v13020149
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发表时间:
2021-01-20
期刊:
Viruses
影响因子:
--
通讯作者:
Zverev V
Zverev V
中科院分区:
其他
文献类型:
--
作者:
Krylov V;Bourkaltseva M;Pleteneva E;Shaburova O;Krylov S;Karaulov A;Zhavoronok S;Svitich O;Zverev V

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本文涵盖了phiKZ的发现和描述的历史,phiKZ是第一个已知的对铜绿假单胞菌有活性的巨型噬菌体。它还描述了其独特的功能,特别是DNA包装在头部周围的圆柱形结构(“内体”)的特征方式,这可能决定了噬菌体基因组的有序和紧密包装。phiKZ样细菌的重要特性包括广泛的裂解活性和其阴性菌落的蓝色乳光,并为寻找和发现新的铜绿假单胞菌巨型细菌提供了背景。phiKZ种类和其他巨噬菌体种类在实际噬菌体治疗中的重要性被注意到,因为它们在商业噬菌体制剂中广泛使用。
The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on Pseudomonas aeruginosa. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (“inner body”), which probably governs an ordered and tight packaging of the phage genome. Important properties of phiKZ-like phages include a wide range of lytic activity and the blue opalescence of their negative colonies, and provide a background for the search and discovery of new P. aeruginosa giant phages. The importance of the phiKZ species and of other giant phage species in practical phage therapy is noted given their broad use in commercial phage preparations.
针对杀鲑气单胞菌的噬菌体混合物的体外设计和评估
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