Importance of environmental context for one- and three-trial cocaine-induced behavioral sensitization in preweanling rats.
Importance of environmental context for one- and three-trial cocaine-induced behavioral sensitization in preweanling rats.
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DOI：
10.1007/s00213-009-1616-2
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发表时间：
2009-10
影响因子：
3.4
通讯作者：
Amodeo, Dionisio A.
中科院分区：
文献类型：
--
作者：
McDougall, Sanders A.;Cortez, Anthony M.;Palmer, Alexandria G.;Herbert, Matthew S.;Martinez, Cynthia E.;Charntikov, Sergios;Amodeo, Dionisio A.
与成年大鼠不同，断奶前大鼠在单次预处理注射可卡因后表现出与上下文无关的行为敏化。本研究的目的是研究环境因素调制的一个和三个试验致敏断奶前大鼠。对于断奶前大鼠，在PD 17-PD 19（实验1）或PD 19（实验2）进行药物预处理。一组大鼠注射可卡因（30毫克/公斤），并放置在麻醉（“小”），操作性条件反射（“大”），或活动室30分钟。大鼠返回到家笼，注射生理盐水。另外几组大鼠注射生理盐水，并放置在小、大或活动室中30分钟，然后在返回到饲养笼后注射可卡因。对照组在两个时间点注射生理盐水。在单独的实验中，大鼠用可卡因或盐水预处理，并限制在笼子里。PD 20时，所有大鼠注射可卡因（20 mg/kg），并放置在活动室中，评估自发活动60 min。出于比较目的，还评估了成年大鼠的致敏性。成年雄性和雌性大鼠仅表现出情境依赖性致敏，而断奶前大鼠在各种条件下表现出情境独立性致敏（例如，当在各种新的室或饲养笼中用可卡因预处理时）。这些结果表明，行为敏化的非关联机制在断奶前大鼠的功能是成熟的，但关联过程中调制的敏感反应的强度不起作用，在断奶前的成年人一样的方式。
Preweanling rats, unlike adults, exhibit context-independent behavioral sensitization after a single pretreatment injection of cocaine. The purpose of this study was to examine environmental factors modulating one- and three-trial sensitization in preweanling rats. For preweanling rats, drug pretreatments occurred on PD 17–PD 19 (Experiment 1) or PD 19 (Experiment 2). One set of rats was injected with cocaine (30 mg/kg) and placed in anesthesia (“small”), operant conditioning (“large”), or activity chambers for 30 min. Rats were returned to the home cage and injected with saline. Additional groups of rats were injected with saline and placed in small, large, or activity chambers for 30 min and then injected with cocaine after being returned to the home cage. Control groups were injected with saline at both time points. In separate experiments, rats were pretreated with cocaine or saline and restricted to the home cage. On PD 20, all rats were injected with cocaine (20 mg/kg) and placed in activity chambers where locomotor activity was assessed for 60 min. For comparison purposes, sensitization was also assessed in adult rats. Adult male and female rats exhibited only context-dependent sensitization, whereas preweanling rats showed context-independent sensitization in a variety of conditions (e.g., when pretreated with cocaine in various novel chambers or the home cage). These results suggest that nonassociative mechanisms underlying behavioral sensitization are functionally mature in preweanling rats, but associative processes modulating the strength of the sensitized response do not function in an adult-like manner during the preweanling period.
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影响因子：
5
作者：
Bolanos, CA;Garmsen, GM;McDougall, SA
通讯作者：
McDougall, SA
影响因子：
2.7
作者：
Carey, RJ;Gui, JM
通讯作者：
Gui, JM
影响因子：
1.9
作者：
Anagnostaras, SG;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
3.4
作者：
KOLTA, MG;SCALZO, FM;HOLSON, RR
通讯作者：
HOLSON, RR
影响因子：
3.4
作者：
McDougall, SA;Reichel, CM;Crawford, CA
通讯作者：
Crawford, CA