Multimodal exploration of the intracranial aneurysm wall.
Multimodal exploration of the intracranial aneurysm wall.
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DOI：
10.1007/s11548-023-02850-0
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发表时间：
2023-12
影响因子：
3
通讯作者：
Saalfeld, Sylvia
中科院分区：
文献类型：
--
作者：
Niemann, Annika;Tulamo, Riikka;Netti, Eliisa;Preim, Bernhard;Berg, Philipp;Cebral, Juan;Robertson, Anne;Saalfeld, Sylvia
颅内动脉瘤(IAS)是临床影像资料只能显示血管管腔的颅内血管壁的病理改变。组织学可以提供壁部信息，但通常仅限于组织形状发生变化的体外2D切片。我们开发了一个可视化的勘探管道，用于全面查看IA。我们提取多模式信息(如组织图像的染色分类和分割)，并通过2D到3D映射和变形组织的虚拟膨胀来组合它们。组织学数据，包括四种染色、显微CT数据和节段性钙化以及血流动力学信息，如壁切应力(WSS)，与切除的动脉瘤的3D模型相结合。钙化多见于组织部位，WSS增加。在3D模型中，发现了一个壁厚增加的区域，并与组织学相关联，其中油红O(ORO)染色的图像显示脂质堆积，而α-平滑肌肌动蛋白(ASMA)染色的图像显示肌肉细胞轻微丢失。我们的可视化探测管道结合了有关动脉瘤管壁的多模式信息，以提高对管壁变化和IA发展的了解。用户可以识别区域并关联如何通过血管壁、壁厚和钙化的组织结构来反映血流动力，例如WSS。
Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restricted to ex vivo 2D slices where the shape of the tissue is altered. We developed a visual exploration pipeline for a comprehensive view of an IA. We extract multimodal information (like stain classification and segmentation of histologic images) and combine them via 2D to 3D mapping and virtual inflation of deformed tissue. Histological data, including four stains, micro-CT data and segmented calcifications as well as hemodynamic information like wall shear stress (WSS), are combined with the 3D model of the resected aneurysm. Calcifications were mostly present in the tissue part with increased WSS. In the 3D model, an area of increased wall thickness was identified and correlated to histology, where the Oil red O (ORO) stained images showed a lipid accumulation and the alpha-smooth muscle actin (aSMA) stained images showed a slight loss of muscle cells. Our visual exploration pipeline combines multimodal information about the aneurysm wall to improve the understanding of wall changes and IA development. The user can identify regions and correlate how hemodynamic forces, e.g. WSS, are reflected by histological structures of the vessel wall, wall thickness and calcifications.
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影响因子：
3.5
作者：
Matsushige, T.;Chen, B.;Wrede, K. H.
通讯作者：
Wrede, K. H.
影响因子：
--
作者：
Ajiboye N;Chalouhi N;Starke RM;Zanaty M;Bell R
通讯作者：
Bell R
DOI：
10.1109/34.121791
发表时间：
1992-02-01
影响因子：
23.6
作者：
BESL, PJ;MCKAY, ND
通讯作者：
MCKAY, ND
影响因子：
4.8
作者：
Kadasi, Laith M.;Dent, Walter C.;Malek, Adel M.
通讯作者：
Malek, Adel M.
DOI：
10.1007/s11548-019-01986-2
发表时间：
2019-10-01
影响因子：
3
作者：
Berg, Philipp;Voss, Samuel;Beuing, Oliver
通讯作者：
Beuing, Oliver