Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050.
Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050.
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DOI：
10.1016/j.xinn.2023.100450
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发表时间：
2023-07-10
期刊：
影响因子：
32.1
通讯作者：
Yang, Bo-Yi
中科院分区：
文献类型：
--
作者：
Qiu, Hui -Ling;Fan, Shujun;Zhou, Kaixin;He, Zhini;Browning, Matthew H. E. M.;Knibbs, Luke D.;Zhao, Tianyu;Luo, Ya-Na;Liu, Xiao-Xuan;Hu, Li-Xin;Li, Jia-Xin;Zhang, Yi-Dan;Xie, Yu-Ting;Heinrich, Joachim;Dong, Guang-Hui;Yang, Bo-Yi
高血糖是世界范围内死亡和残疾的关键风险因素。为了更好地为预防策略提供信息，我们的目标是描绘和预测全球平均空腹血糖(FPG)水平及其相关疾病负担的时间、空间和人口模式。基于2019年全球疾病负担研究，我们估计了1990-2050年按年龄、性别、年份、社会经济地位(SES)和地理区域划分的平均空腹血糖水平和高空腹血糖相关疾病负担的分布。我们还调查了人口、行为、饮食、代谢和环境因素与空腹血糖水平和高空腹血糖相关疾病负担的可能关联。2019年，全球平均空腹血糖水平为5.40亿mmol/L(95%不确定区间：4.86-6.00)，高空腹血糖导致每10万人83.0例死亡(95%UI，64.5%-107.1)和2104.3DALY(95%UI：1,740.7-2520.7)。在历史时期(1990-2019年)和未来时期(2020-2050年)，全球平均空腹血糖水平和与空腹血糖相关的高疾病负担都有所增加，其中中老年人和中低收入国家的增加幅度更大。老龄化、不健康的生活方式、高体重指数和较低的气温是高空腹血糖水平和高空腹血糖相关疾病负担的潜在危险因素。这项研究表明，高空腹血糖继续造成全球疾病负担，预计至少在未来30年内会如此。老年人和那些生活在低至中等SES国家的人应该在血糖管理健康干预方面得到更多的关注。此外，应采取针对已确定的危险因素的有效干预措施，以应对因高空腹血糖而造成的日益沉重的疾病负担。从1990年到2019年，全球平均空腹血糖(FPG)水平有所上升。从1990年到2050年，全球与空腹血糖相关的高疾病负担增加。空腹血糖水平和疾病负担显示出年龄和社会经济的异质性。老龄化、不健康的生活方式、体重指数升高和低温都是危险因素。
Hyperglycemia is a key risk factor for death and disability worldwide. To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. Based on the Global Burden of Disease Study 2019, we estimated the distributions of mean FPG levels and high FPG-related disease burden by age, sex, year, socioeconomic status (SES), and geographical region from 1990 to 2050. We also investigated the possible associations of demographic, behavioral, dietary, metabolic, and environmental factors with FPG levels and high FPG-related disease burden. In 2019, the global mean FPG level was 5.40 mmol/L (95% uncertainty interval [UI]: 4.86–6.00), and high FPG contributed to 83.0 deaths (95% UI, 64.5–107.1) and 2,104.3 DALYs (95% UI: 1,740.7–2,520.7) per 100,000 people. For both historical (1990–2019) and future (2020–2050) periods, the mean FPG levels and the high FPG-related disease burden increased globally, with greater increases among the middle-aged and elderly, and people in low-to-middle SES countries, relative to their counterparts. Aging, unhealthy lifestyles, elevated body mass index, and lower air temperatures were potential risk factors for high FPG levels and the high FPG-related disease burden. This study demonstrates that high FPG continues to contribute to the global disease burden and is expected to do so for at least the next 30 years. Older people and those living in low-to-middle SES countries should receive more attention in glycemic management health interventions. In addition, effective interventions that target identified risk factors should be adopted to handle the increasingly large disease burden of high FPG. Mean fasting plasma glucose (FPG) levels increased globally from 1990 to 2019. High FPG-related disease burden increased globally from 1990 to 2050. FPG levels and their disease burden showed age and socioeconomic heterogeneities. Aging, unhealthy lifestyles, elevated body mass index, and low temperatures are risk factors.
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DOI：
10.1016/s0140-6736(22)01438-6
发表时间：
2022-08-20
期刊：
Lancet (London, England)
影响因子：
--
作者：
通讯作者：
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影响因子：
10.4
作者：
Clougherty JE
通讯作者：
Clougherty JE
影响因子：
16.2
作者：
Bommer, Christian;Sagalova, Vera;Vollmer, Sebastian
通讯作者：
Vollmer, Sebastian
影响因子：
5.9
作者：
Fan R;Xu M;Wang J;Zhang Z;Chen Q;Li Y;Gu J;Cai X;Guo Q;Bao L;Li Y
通讯作者：
Li Y
影响因子：
44.5
作者：
Afzal, Shoaib;Brondum-Jacobsen, Peter;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.