The Relationship between Mucins and Ulcerative Colitis: A Systematic Review.
The Relationship between Mucins and Ulcerative Colitis: A Systematic Review.
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DOI：
10.3390/jcm10091935
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发表时间：
2021-04-30
影响因子：
3.9
通讯作者：
Garnett JA
中科院分区：
文献类型：
--
作者：
Bankole E;Read E;Curtis MA;Neves JF;Garnett JA
粘蛋白是糖基化蛋白质家族，其是粘液的主要成分，并且在整个人体的保护性粘膜屏障的调节中发挥动态作用。溃疡性结肠炎（UC）是一种炎症性肠病（IBD），其特征是大肠内层的持续炎症，在本系统综述中，我们分析了目前可用的数据，以确定UC患者结肠粘膜中粘蛋白活性是否存在改变。进行数据库检索，以识别1990年至2020年期间发表的评估粘蛋白在UC患者队列中作用的研究，其中切除活检标本进行分析，并纳入对照组进行比较。最初识别了5497篇文章，并系统地选择了其中的14项研究进行分析，通过引文链识别了另外2篇文章。因此，对16项研究进行了严格审查。其中13项研究评估了MUC2在UC中的作用，大多数文章表明MUC2结构或合成的改变对结肠粘膜有影响，尽管关于MUC2表达的结果相互矛盾。这篇综述强调了进一步研究的重要性，以提高我们对UC粘蛋白调控的理解，并总结了可能为未来研究提供信息的数据。
Mucins are a family of glycosylated proteins which are the primary constituents of mucus and play a dynamic role in the regulation of the protective mucosal barriers throughout the human body. Ulcerative colitis (UC) is an Inflammatory Bowel Disease (IBD) characterised by continuous inflammation of the inner layer of the large intestine, and in this systematic review we analyse currently available data to determine whether alterations exist in mucin activity in the colonic mucosa of UC patients. Database searches were conducted to identify studies published between 1990 and 2020 that assess the role of mucins in cohorts of UC patients, where biopsy specimens were resected for analysis and control groups were included for comparison. 5497 articles were initially identified and of these 14 studies were systematically selected for analysis, a further 2 articles were identified through citation chaining. Therefore, 16 studies were critically reviewed. 13 of these studies assessed the role of MUC2 in UC and the majority of articles indicated that alterations in MUC2 structure or synthesis had an impact on the colonic mucosa, although conflicting results were presented regarding MUC2 expression. This review highlights the importance of further research to enhance our understanding of mucin regulation in UC and summarises data that may inform future studies.
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影响因子：
10.7
作者：
Lang T;Klasson S;Larsson E;Johansson ME;Hansson GC;Samuelsson T
通讯作者：
Samuelsson T
影响因子：
13.8
作者：
Ciccarelli, FD;Doerks, T;Bork, P
通讯作者：
Bork, P
影响因子：
64.5
作者：
Javitt G;Khmelnitsky L;Albert L;Bigman LS;Elad N;Morgenstern D;Ilani T;Levy Y;Diskin R;Fass D
通讯作者：
Fass D
影响因子：
4.7
作者：
Moehle, Christoph;Ackermann, Nikolaus;Schmitz, Gerd
通讯作者：
Schmitz, Gerd
影响因子：
5.6
作者：
Matijašić M;Meštrović T;Perić M;Čipčić Paljetak H;Panek M;Vranešić Bender D;Ljubas Kelečić D;Krznarić Ž;Verbanac D
通讯作者：
Verbanac D