Liver transient elastography values in healthy South African children.
Liver transient elastography values in healthy South African children.
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健康南非儿童的肝瞬时弹性学值。
DOI：
10.1186/s12887-023-04170-3
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发表时间：
2023-07-13
期刊：
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
瞬态弹性成像（TE）是一种基于超声的快速无创技术，可测量肝脏硬度作为肝纤维化的替代指标，控制衰减参数（CAP）作为肝脏脂肪变性的测量指标。然而，儿童的正常范围并不是在所有人群中都有很好的定义。本研究的目的是确定健康南非儿童的瞬时弹性成像值。从2019年4月到2021年12月，从一项队列研究的艾滋病毒阴性对照组中招募了儿童。只有既不超重也不肥胖的儿童，没有肝脏疾病的证据，没有与肝脂肪变性或纤维化相关的医疗条件或药物，以及正常的代谢特征被纳入本横断面分析。当日采集临床资料、人体测量和血液样本，并进行衰减参数可控的瞬态弹性成像。纳入104例儿童（中位年龄12.8岁[IQR 11.4-14.8，范围7.9-17.7岁]；59例[57%]男孩）。肝硬度与年龄呈正相关（Pearson’s r = 0.39, p < 0.001）。男孩的中位肝硬度（5.2 kPa[第5至95百分位数3.6至6.8 kPa]）高于女孩（4.6 kPa[第5至95百分位数3.6至6.1 kPa; p = 0.004]），但种族间无差异。CAP中位数为179dB/m（第5至第95百分位数为158至233dB/m）。CAP与身体质量指数（BMI） z-score呈正相关，但与年龄、性别、种族和青春期状态无显著差异。肝脏硬度值随年龄增长而增加，健康的南非男孩比女孩高，而CAP值随BMI变化，但不随年龄或性别变化。
Transient elastography (TE) is a rapid noninvasive ultrasound-based technology that measures liver stiffness as a surrogate for liver fibrosis and controlled attenuation parameter (CAP) as a measure of liver steatosis. However, normal ranges in children are not well defined in all populations. The aim of this study was to determine transient elastography values in healthy South African children. From April 2019 to December 2021, children were recruited from the HIV negative control group of a cohort study. Only children neither overweight nor obese, without evidence of liver disease, no medical condition or medication associated with hepatic steatosis or fibrosis and normal metabolic profile were included in this cross-sectional analysis. Clinical data, anthropometry and blood samples were collected on the same day as transient elastography with controlled attenuation parameter was performed. 104 children (median age 12.8 years [IQR 11.4–14.8, range 7.9–17.7 years]; 59 [57%] boys) were included. Liver stiffness was positively correlated with age (Pearson’s r = 0.39, p < 0.001). Median liver stiffness in boys (5.2 kPa [5th to 95th percentiles 3.6 to 6.8 kPa]) was greater than in girls (4.6 kPa [5th to 95th percentiles 3.6 to 6.1 kPa; p = 0.004]), but there was no difference by ethnicity. Median CAP was 179dB/m (5th to 95th percentiles 158 to 233dB/m). There was a positive correlation between CAP and body mass index (BMI) z-score, but no difference by age, sex, ethnicity or pubertal status. Liver stiffness values increase with age and are higher in healthy South African boys than girls, whereas CAP values vary with BMI, but not with age or sex.
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DOI：
10.1097/mpg.0000000000002991
发表时间：
2021-03-01
影响因子：
2.9
作者：
Mandelia, Chetan;Kabbany, Mohammad Nasser;Selvakumar, Praveen Kumar Conjeevaram
通讯作者：
Selvakumar, Praveen Kumar Conjeevaram
DOI：
10.1097/mpg.0b013e31826f2760
发表时间：
2013-01-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
2.4
作者：
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通讯作者：
Waked, Imam
影响因子：
158.5
作者：
Palumbo, Paul;Lindsey, Jane C.;Violari, Avy
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Violari, Avy
影响因子：
2.3
作者：
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Asal, Nese