Complexity of low-frequency blood oxygen level-dependent fluctuations covaries with local connectivity.
Complexity of low-frequency blood oxygen level-dependent fluctuations covaries with local connectivity.
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DOI：
10.1002/hbm.22251
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发表时间：
2014-04
影响因子：
4.8
通讯作者：
Ferguson, Michael A.
中科院分区：
文献类型：
--
作者：
Anderson, Jeffrey S.;Zielinski, Brandon A.;Nielsen, Jared A.;Ferguson, Michael A.
关键词：
极低频血氧水平依赖性（BOLD）波动已成为描述大脑解剖、神经病理学和发育的宝贵工具。这种波动表现出幂律频率动态，在最低频率处具有最大幅度。人们对产生这种波动的生物物理机制知之甚少。使用公开的数据，从1019名7-30岁的受试者，我们发现，BOLD波动表现出时间的复杂性，是线性相关的局部连接（区域同质性），一致和显着的协变跨学科和跨灰质区域。这种关系持续独立的协方差与灰质密度或标准偏差的BOLD信号。在神经发育后期，BOLD波动在联合皮层中没有随年龄变化，而在大脑的其他部分变得更加随机。这些数据表明，局部互连可能发挥关键作用，在建立低频BOLD波动的复杂性功能性MRI连接。在分布式大规模脑网络的发展过程中，通过连接的分割和整合，可能会出现稳定的低频功率动态。
Very low frequency blood oxygen level dependent (BOLD) fluctuations have emerged as a valuable tool for describing brain anatomy, neuropathology, and development. Such fluctuations exhibit power law frequency dynamics, with largest amplitude at lowest frequencies. The biophysical mechanisms generating such fluctuations are poorly understood. Using publicly available data from 1019 subjects of age 7-30, we show that BOLD fluctuations exhibit temporal complexity that is linearly related to local connectivity (regional homogeneity), consistently and significantly covarying across subjects and across gray matter regions. This relationship persisted independently of covariance with gray matter density or standard deviation of BOLD signal. During late neurodevelopment, BOLD fluctuations were unchanged with age in association cortex while becoming more random throughout the rest of the brain. These data suggest that local interconnectivity may play a key role in establishing the complexity of low frequency BOLD fluctuations underlying functional MRI connectivity. Stable low frequency power dynamics may emerge through segmentation and integration of connectivity during development of distributed large-scale brain networks.
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HD-200 Consortium
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