Randomized web-based physical activity intervention in adolescent survivors of childhood cancer.

Randomized web-based physical activity intervention in adolescent survivors of childhood cancer.
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DOI:
10.1002/pbc.27216
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发表时间:
2018-08
影响因子:
3.2
通讯作者:
Ness KK
Ness KK
中科院分区:
医学3区
文献类型:
--
作者:
Howell CR;Krull KR;Partin RE;Kadan-Lottick NS;Robison LL;Hudson MM;Ness KK

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健康的生活方式选择,包括定期参加体育活动,可以改善儿童癌症幸存者的健康状况。我们的目的是评估青少年幸存者中的网络交付的身体活动干预的有效性,以增加中度到剧烈的身体活动(MVPA),并改善健身,神经认知和健康相关的生活质量(HRQoL)超过24周。这项随机对照试验在单一机构治疗的幸存者(年龄≥ 11至< 15岁)中进行。参与者被随机分配到通过互联网提供的身体活动干预组或对照组。干预组收到教育材料,活动监视器和访问一个互动网站,旨在通过奖励激励增加体力活动;对照组收到活动监视器和教育材料。在基线和24周时评估身体活动、健康、神经认知和HRQoL结局。使用配对t检验比较组间的平均变化。在入组的97名幸存者中,78名完成了研究,平均年龄为12.7岁(SD 1.1),80%为白色,55.1%为女性。53名幸存者被分配到干预组,25名被分配到对照组。虽然干预组的幸存者每周MVPA增加,而对照组的幸存者每周MVPA减少(4.7±119.9分钟vs-24.3±89.7分钟),但这种差异并不显着(p=0.30)。然而,干预组的握力、仰卧起坐和俯卧撑次数、神经认知功能和HRQoL结果有所改善,但对照组没有改善。一个互动的,奖励为基础的干预措施,旨在增加MVPA是可行的青少年幸存者的儿童癌症。
Healthy lifestyle choices including participation in regular physical activity may improve health outcomes in survivors of childhood cancer. We aimed to evaluate the efficacy of a web-delivered, physical activity intervention among adolescent survivors to increase moderate-to-vigorous physical activity (MVPA) and improve fitness, neurocognitive and health-related quality of life (HRQoL) over 24-weeks. This randomized controlled trial was conducted among survivors (aged ≥ 11 to < 15 years) treated at a single institution. Participants were randomized to either a physical activity intervention delivered over the internet or a control group. The intervention group received educational materials, an activity monitor and access to an interactive website designed to motivate increased physical activity via rewards; the control group received an activity monitor and educational materials. Physical activity, fitness, neurocognitive and HRQoL outcomes were assessed at baseline and 24-weeks. Mean changes were compared between groups using paired t-tests. Of 97 survivors enrolled, 78 completed the study, mean age was 12.7 (SD 1.1), 80% were white, and 55.1% were female. Fifty-three survivors were assigned to the intervention and 25 to the control group. While survivors in the intervention group increased, and those in the control group decreased (4.7±119.9 vs. −24.3±89.7 minutes) weekly MVPA, this difference was not significant (p=0.30). However, hand grip strength, number of sit-ups and pushups, neurocognitive function, and HRQoL outcomes improved in the intervention, but not in the control group. An interactive, rewards based intervention designed to increase MVPA is feasible in adolescent survivors of childhood cancer.
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