Adolescent TBI‐induced hypopituitarism causes sexual dysfunction in adult male rats
Adolescent TBI‐induced hypopituitarism causes sexual dysfunction in adult male rats
复制标题
青少年 TBI 诱发的垂体功能低下导致成年雄性大鼠性功能障碍
作者：
T. Greco;D. Hovda;M. Prins
青少年发生创伤性脑损伤 (TBI) 和重复性脑损伤 (RTBI) 的风险最大。 TBI 引起的垂体功能减退症在成人和青少年中都有记录，尽管垂体功能对于正常的身体和大脑发育是必要的，但在 TBI 后的青少年中，它仍然未被认识和治疗。 TBI 在关键发育窗口期间引起的激素功能障碍有可能导致长期的认知和行为缺陷，而这个话题目前仍未得到解决。本研究的目的是确定给予青春期雄性大鼠的四种轻度 TBI 是否会破坏睾酮的产生和成年行为结果。从受伤前 72 小时到受伤后 3 个月对血浆睾酮进行定量，并在受伤后 1 个月和 2 个月评估青春期开始、生殖器官生长、勃起功能和生殖行为。 RTBI 导致睾酮生成的急性和慢性减少以及青春期延迟。成年大鼠受伤后 1 个月和 2 个月的生殖器官生长、勃起功能和生殖行为均观察到显着缺陷。这些数据表明青少年 RTBI 诱发的垂体功能低下是成年期观察到的异常行为变化的基础。青春期 RTBI 后未确诊的垂体功能减退症不仅对生长和青春期具有重要意义，而且对成年后的大脑发育和神经行为功能也具有重要意义。 © 2014 Wiley periodicals, Inc. Develop Neurobiol 75: 193–202, 2015
Adolescents are at greatest risk for traumatic brain injury (TBI) and repeat TBI (RTBI). TBI‐induced hypopituitarism has been documented in both adults and juveniles and despite the necessity of pituitary function for normal physical and brain development, it is still unrecognized and untreated in adolescents following TBI. TBI induced hormonal dysfunction during a critical developmental window has the potential to cause long‐term cognitive and behavioral deficits and the topic currently remains unaddressed. The purpose of this study was to determine if four mild TBIs delivered to adolescent male rats disrupts testosterone production and adult behavioral outcomes. Plasma testosterone was quantified from 72 hrs preinjury to 3 months postinjury and pubertal onset, reproductive organ growth, erectile function and reproductive behaviors were assessed at 1 and 2 months postinjury. RTBI resulted in both acute and chronic decreases in testosterone production and delayed onset of puberty. Significant deficits were observed in reproductive organ growth, erectile function and reproductive behaviors in adult rats at both 1 and 2 months postinjury. These data suggest adolescent RTBI‐induced hypopituitarism underlies abnormal behavioral changes observed during adulthood. The impact of undiagnosed hypopituitarism following RTBI in adolescence has significance not only for growth and puberty, but also for brain development and neurobehavioral function as adults. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 193–202, 2015
影响因子：
4.2
作者：
Greco, Tiffany;Hovda, David;Prins, Mayumi
通讯作者：
Prins, Mayumi
影响因子：
2.2
作者：
PRIMUS, RJ;KELLOGG, CK
通讯作者：
KELLOGG, CK
影响因子：
2.2
作者：
Vetter-O'Hagen, Courtney S.;Spear, Linda P.
通讯作者：
Spear, Linda P.