Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
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DOI：
10.3390/cells11091568
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发表时间：
2022-05-06
期刊：
影响因子：
6
通讯作者：
Rallis, Charalampos
中科院分区：
文献类型：
--
作者：
Dabrowska, Aleksandra;Kumar, Juhi;Rallis, Charalampos
关键词：
细胞、小型无脊椎动物和脊椎动物模型是生物老年学研究的推动力。利用各种模型，如酵母菌、适当的组织培养细胞、果蝇、线虫和小鼠，极大地增加了我们对饮食、营养反应信号通路和寿命调节之间关系的了解。近年来，组合药物治疗与诱变、高通量筛选以及多组学方法相结合，为研究细胞的新陈代谢、发育、分化和衰老提供了前所未有的见解。因此，科学家们正朝着表征生长和压力途径的精细结构和相互作用的方向前进，以确定可能的干预措施，从而导致人类健康老龄化和改善与年龄相关的疾病。在这篇简短的综述中，我们简要回顾了最近发现的关于营养反应通路的知识，如胰岛素生长因子(IGF)和雷帕霉素信号通路的机制靶点，以及特定的GWAs和一些EWAs关于寿命和年龄相关疾病的研究，这些研究增进了我们在老龄化和生物老年学领域的当前理解。我们讨论了从丰富和多样化的生成数据中学到了什么，以及这些科学学科的挑战和下一步的前沿。
Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and the mouse, has tremendously increased our knowledge around the relationship between diet, nutrient-response signaling pathways and lifespan regulation. In recent years, combinatorial drug treatments combined with mutagenesis, high-throughput screens, as well as multi-omics approaches, have provided unprecedented insights in cellular metabolism, development, differentiation, and aging. Scientists are, therefore, moving towards characterizing the fine architecture and cross-talks of growth and stress pathways towards identifying possible interventions that could lead to healthy aging and the amelioration of age-related diseases in humans. In this short review, we briefly examine recently uncovered knowledge around nutrient-response pathways, such as the Insulin Growth Factor (IGF) and the mechanistic Target of Rapamycin signaling pathways, as well as specific GWAS and some EWAS studies on lifespan and age-related disease that have enhanced our current understanding within the aging and biogerontology fields. We discuss what is learned from the rich and diverse generated data, as well as challenges and next frontiers in these scientific disciplines.
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影响因子：
6
作者：
Castejón-Vega B;Rubio A;Pérez-Pulido AJ;Quiles JL;Lane JD;Fernández-Domínguez B;Cachón-González MB;Martín-Ruiz C;Sanz A;Cox TM;Alcocer-Gómez E;Cordero MD
通讯作者：
Cordero MD
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
4.8
作者：
Bake, Shameena;Okoreeh, Andre K.;Sohrabji, Farida
通讯作者：
Sohrabji, Farida
DOI：
10.1042/bcj20210432
发表时间：
2021-12-22
期刊：
The Biochemical journal
影响因子：
--
作者：
Campion R;Bloxam L;Burrow K;Brownridge PJ;Pentland DR;Thomas P;Gourlay CW;Eyers CE;Barclay JW;Morgan A
通讯作者：
Morgan A
SAR1B 感知亮氨酸水平来调节 mTORC1 信号传导
影响因子：
64.8
作者：
Chen, Jie;Ou, Yuhui;Liu, Ying
通讯作者：
Liu, Ying