Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells.
Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells.
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DOI：
10.1155/2016/2759403
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发表时间：
2016
影响因子：
4.3
通讯作者：
Hugnot JP
中科院分区：
文献类型：
--
作者：
Guelfi S;Duffau H;Bauchet L;Rothhut B;Hugnot JP
胶质母细胞瘤是破坏性的和广泛血管化的脑肿瘤，胶质母细胞瘤干细胞样细胞（GSC）已被许多研究小组分离出来。这些细胞具有高致瘤潜力和产生异质表型的能力。越来越多的证据支持这些细胞来源于成体神经干细胞（NSC）以及少突胶质细胞祖细胞中突变积累的可能性。近年来研究发现，在Notch和TGFβ信号通路的影响下，GSCs在体内外均可转分化为内皮样细胞和周细胞样细胞。还在患者样品中直接观察到源自GBM细胞的血管细胞。这些结果可能会导致新的方向，设计原始的治疗方法对GBM新生血管，但这种特定的重编程需要进一步的分子研究。非肿瘤神经干细胞向血管细胞的转分化也已被描述，相反，血管细胞可产生神经干细胞。在本文中，我们介绍并讨论了这些最新数据。由于其中一些存在争议，因此需要使用新的技术方法进行进一步验证，如高通量分析和功能分析，以避免实验陷阱和误解。
Glioblastomas are devastating and extensively vascularized brain tumors from which glioblastoma stem-like cells (GSCs) have been isolated by many groups. These cells have a high tumorigenic potential and the capacity to generate heterogeneous phenotypes. There is growing evidence to support the possibility that these cells are derived from the accumulation of mutations in adult neural stem cells (NSCs) as well as in oligodendrocyte progenitors. It was recently reported that GSCs could transdifferentiate into endothelial-like and pericyte-like cells both in vitro and in vivo, notably under the influence of Notch and TGFβ signaling pathways. Vascular cells derived from GBM cells were also observed directly in patient samples. These results could lead to new directions for designing original therapeutic approaches against GBM neovascularization but this specific reprogramming requires further molecular investigations. Transdifferentiation of nontumoral neural stem cells into vascular cells has also been described and conversely vascular cells may generate neural stem cells. In this review, we present and discuss these recent data. As some of them appear controversial, further validation will be needed using new technical approaches such as high throughput profiling and functional analyses to avoid experimental pitfalls and misinterpretations.
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影响因子：
16.6
作者：
Chen, Hsiao-Fan;Huang, Chi-Hung;Wu, Kou-Juey
通讯作者：
Wu, Kou-Juey
胶质瘤血管化的新镶嵌模式：外源内皮祖细胞整合到含有肿瘤源性内皮细胞的血管中
影响因子：
--
作者：
Chen X;Fang J;Wang S;Liu H;Du X;Chen J;Li X;Yang Y;Zhang B;Zhang W
通讯作者：
Zhang W
影响因子：
7.7
作者：
Chroscinski D;Sampey D;Maherali N;Reproducibility Project: Cancer Biology;Reproducibility Project Cancer Biology
通讯作者：
Reproducibility Project Cancer Biology
影响因子：
11.8
作者：
Bjornsson CS;Apostolopoulou M;Tian Y;Temple S
通讯作者：
Temple S
DOI：
10.1161/atvbaha.111.232934
发表时间：
2011-10
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Boscolo E;Stewart CL;Greenberger S;Wu JK;Durham JT;Herman IM;Mulliken JB;Kitajewski J;Bischoff J
通讯作者：
Bischoff J