Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases.

Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases.
复制标题

寡核苷酸适体:有前途且强大的传染病诊断和治疗工具。

DOI:
10.1016/j.jinf.2018.04.007
复制
发表时间:
2018-08
期刊:
The Journal of infection
影响因子:
--
通讯作者:
Zhang XL
Zhang XL
中科院分区:
其他
文献类型:
--
作者:
Pan Q;Luo F;Liu M;Zhang XL

文献摘要

参考文献

被引文献

相似文献

全世界所有人口都面临传染病的危险。迄今为止,由于缺乏有效的探针来识别和识别病原体的生物标志物,在分子和纳米水平上诊断和治疗人类传染病一直是极具挑战性的任务。寡核苷酸适配体是一类由单链DNA (ssDNA)或RNA组成的核酸小配体,是多种靶标的亲和探针或分子识别元件。这些适体在诊断和/或治疗特定疾病方面具有令人兴奋的潜力。在这篇综述中,我们重点介绍了适体在细菌和病毒感染性疾病的诊断和治疗方面以及基于适体的检测方面的研究进展。
The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets. These aptamers have an exciting potential for diagnose and/or treatment of specific diseases. In this review, we highlight areas where aptamers have been developed as diagnostic and therapeutic agents for both bacterial and viral infectious diseases as well as aptamer-based detection.
DOI: 10.1007/s00894-014-2380-8
发表时间: 2014-08-01
影响因子: 2.2
作者:
Aeksiri, Niran;Songtawee, Napat;Choowongkomon, Kiattawee
通讯作者: Choowongkomon, Kiattawee
DOI: 10.1016/j.bbapap.2015.05.003
发表时间: 2015-10-01
影响因子: 3.2
作者:
Baig, Irshad Ahmed;Moon, Ji-Young;Yoon, Moon-Young
通讯作者: Yoon, Moon-Young
DOI: 10.3390/molecules20046866
发表时间: 2015-04-16
期刊: Molecules (Basel, Switzerland)
影响因子: --
作者:
Bruno JG
通讯作者: Bruno JG
DOI: 10.1007/s12223-008-0046-6
发表时间: 2008-07-01
影响因子: 2.6
作者:
Bruno, J. G.;Carrillo, M. P.;Phillips, T.
通讯作者: Phillips, T.
DOI: 10.1161/circulationaha.107.745687
发表时间: 2008-06-03
期刊: CIRCULATION
影响因子: 37.8
作者:
Chan, Mark Y.;Cohen, Mauricio G.;Rusconi, Christopher P.
通讯作者: Rusconi, Christopher P.