How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology.
How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology.
复制标题
DOI：
10.1016/j.socscimed.2011.09.036
复制
发表时间：
2012-01
影响因子：
5.4
通讯作者：
Galea, Sandro
中科院分区：
文献类型：
--
作者：
Toyokawa, Satoshi;Uddin, Monica;Koenen, Karestan C.;Galea, Sandro
社会环境在确定主要精神疾病方面起着相当大的作用。新出现的证据表明，社会环境的特征通过表观遗传过程独立于主要DNA序列改变基因表达。因此，表观遗传机制的功能障碍提供了一种合理的机制，通过这种机制，不利的社会环境“进入大脑”，导致心理健康状况不佳。这篇评论的目的是提供一个概述的研究表明，由社会环境引入的表观遗传变化，然后表现为心理后果。我们的目标是建立一个平台，讨论未来的流行病学研究可能受益于包括表观遗传措施的方式。我们专注于精神分裂症，重度抑郁症，创伤后应激障碍，神经性厌食症和物质依赖的例子，突出了社会环境暴露的方式，通过表观遗传过程介导，影响心理健康。
The social environment plays a considerable role in determining major psychiatric disorders. Emerging evidence suggests that features of the social environment modify gene expression independently of the primary DNA sequence through epigenetic processes. Accordingly, dysfunction of epigenetic mechanisms offers a plausible mechanism by which an adverse social environment gets “into the mind” and results in poor mental health. The purpose of this review is to provide an overview of the studies suggesting that epigenetic changes introduced by the social environment then manifest as psychological consequences. Our goal is to build a platform to discuss the ways in which future epidemiologic studies may benefit from including epigenetic measures. We focus on schizophrenia, major depressive disorder, post-traumatic stress disorder, anorexia nervosa, and substance dependence as examples that highlight the ways in which social environmental exposures, mediated through epigenetic processes, affect mental health.
登录
查看更多内容
影响因子：
--
作者：
Costa, E;Chen, Y;Guidotti, A
通讯作者：
Guidotti, A
影响因子：
4.2
作者：
Crum, RM;LillieBlanton, M;Anthony, JC
通讯作者：
Anthony, JC
影响因子：
6.7
作者：
Cornelis, Marilyn C.;Nugent, Nicole R.;Amstadter, Ananda B.;Koenen, Karestan C.
通讯作者：
Koenen, Karestan C.
DOI：
10.1093/jurban/jth138
发表时间：
2004-12-01
影响因子：
6.6
作者：
Breslau, N;Wilcox, HC;Anthony, JC
通讯作者：
Anthony, JC
DOI：
10.1111/j.1530-0277.2006.00068.x
发表时间：
2006-04-01
影响因子：
3.2
作者：
Bleich, S;Lenz, B;Bönsch, D
通讯作者：
Bönsch, D