Dynamic interaction of spindles and gamma activity during cortical slow oscillations and its modulation by subcortical afferents.
Dynamic interaction of spindles and gamma activity during cortical slow oscillations and its modulation by subcortical afferents.
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DOI：
10.1371/journal.pone.0067540
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mena-Segovia J
中科院分区：
文献类型：
--
作者：
Valencia M;Artieda J;Bolam JP;Mena-Segovia J
慢振荡是慢波睡眠的标志。它们为睡眠期间发生的各种阶段性事件提供了一个时间框架，包括高频振荡的表达和整个大脑神经元的放电。有证据表明，在缓慢振荡过程中出现的不同的高频振荡促进了大脑区域之间的交流，这些区域的活动在前一个清醒期是相关的。虽然这种相互作用所涉及的振荡频率已经确定，但它们的动态和它们之间的相互关系需要进一步研究。在这里，我们分析了这些信号在麻醉大鼠的结构和动力学。我们发现，纺锤和伽马振荡共存，但有不同的时间动态在整个缓慢的振荡周期。此外，我们观察到，纺锤体和伽马在功能上耦合到慢振荡和彼此之间。通过在脚桥核注射卡巴胆碱激活脑干的上行通路后，我们能够修改与纺锤体无关的伽马振荡的增益，同时纺锤体振幅降低。此外，卡巴胆碱产生的伽马振荡是依赖于主轴，但没有影响其振幅的去耦。高频振荡的变化都不影响慢振荡的发生或形状，这表明慢振荡的发生独立于与它们共存的相位事件。我们的结果为皮质缓慢振荡的调节、动力学和稳态提供了新的见解。
Slow oscillations are a hallmark of slow wave sleep. They provide a temporal framework for a variety of phasic events to occur and interact during sleep, including the expression of high-frequency oscillations and the discharge of neurons across the entire brain. Evidence shows that the emergence of distinct high-frequency oscillations during slow oscillations facilitates the communication among brain regions whose activity was correlated during the preceding waking period. While the frequencies of oscillations involved in such interactions have been identified, their dynamics and the correlations between them require further investigation. Here we analyzed the structure and dynamics of these signals in anesthetized rats. We show that spindles and gamma oscillations coexist but have distinct temporal dynamics across the slow oscillation cycle. Furthermore, we observed that spindles and gamma are functionally coupled to the slow oscillations and between each other. Following the activation of ascending pathways from the brainstem by means of a carbachol injection in the pedunculopontine nucleus, we were able to modify the gain in the gamma oscillations that are independent of the spindles while the spindle amplitude was reduced. Furthermore, carbachol produced a decoupling of the gamma oscillations that are dependent on the spindles but with no effect on their amplitude. None of the changes in the high-frequency oscillations affected the onset or shape of the slow oscillations, suggesting that slow oscillations occur independently of the phasic events that coexist with them. Our results provide novel insights into the regulation, dynamics and homeostasis of cortical slow oscillations.
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DOI：
10.1523/jneurosci.0077-11.2011
发表时间：
2011-06-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bonjean M;Baker T;Lemieux M;Timofeev I;Sejnowski T;Bazhenov M
通讯作者：
Bazhenov M
影响因子：
4.8
作者：
Poil, Simon-Shlomo;van Ooyen, Arjen;Linkenkaer-Hansen, Klaus
通讯作者：
Linkenkaer-Hansen, Klaus
影响因子：
16.2
作者：
Hughes, SW;Cope, DW;Crunelli, V
通讯作者：
Crunelli, V
影响因子：
14.5
作者：
Csercsa, Richard;Dombovari, Balazs;Ulbert, Istvan
通讯作者：
Ulbert, Istvan
影响因子：
2
作者：
Cox, Roy;Hofman, Winni F.;Talamini, Lucia M.
通讯作者：
Talamini, Lucia M.