Soil Properties and Moisture Synergistically Influence Nontuberculous Mycobacterial Prevalence in Natural Environments of Hawai’i
Soil Properties and Moisture Synergistically Influence Nontuberculous Mycobacterial Prevalence in Natural Environments of Hawai’i
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土壤性质和水分协同影响夏威夷自然环境中非结核分枝杆菌的流行
DOI：
10.1128/aem.00018-22
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发表时间：
2022
影响因子：
4.4
通讯作者：
Leos-Barajas, Vianey
中科院分区：
文献类型：
--
作者：
Parsons, Arielle W.;Dawrs, Stephanie N.;Nelson, Stephen T.;Norton, Grant J.;Virdi, Ravleen;Hasan, Nabeeh A.;Epperson, L. Elaine;Holst, Brady;Chan, Edward D.;Leos-Barajas, Vianey
非结核分枝杆菌（NTM）是引起慢性肺疾病（PD）的机会致病菌。NTM感染被认为是从环境中获得的;然而，驱动和维持NTM流行的基本环境因素还不清楚。据报道，美国NTM PD病例的最高患病率来自夏威夷，夏威夷的气候和土壤成分独特，为调查NTM患病率的环境驱动因素提供了机会。我们使用微生物采样和空间逻辑回归，辅以细尺度土壤矿物学模型的NTM存在的概率在整个夏威夷的自然景观。在过去的7年里，我们从夏威夷群岛自然区的422个地理位置收集了771个样本，并进行了微生物学培养，以确定NTM的存在。在这些样本中有210份（27%）检测到NTM，其中最常见的分离菌种为分枝杆菌。NTM存在的可能性是最高的膨胀土（那些与水膨胀）具有较高的水平衡（>1米的降雨量和蒸散量之间的差异）和丰富的铁氧化物/氢氧化物。我们观察到NTM的存在和铁在潮湿的土壤中，支持过去的研究之间的正相关，但在干燥的土壤中没有这样的关联。高土壤-水平衡可能促进地下运动的NTM进入含水层系统，可能加剧了膨胀的能力，允许裂缝形成在干旱条件下，含水层渗透的进一步可能的途径。这些结果表明，降水和土壤性质的机制，表面NTM可能会达到人类供水。重要的非结核分枝杆菌（NTM）是无处不在的环境中，被发现常见于土壤和自然水体的淡水。然而，很少有人知道NTM的环境小生境，以及它们如何与家庭和其他人类占主导地位的地区的NTM患病率。为了表征NTM环境相关性，我们从美国NTM肺病患病率最高的夏威夷州的自然区域的422个地理位置收集并培养了771个样本。我们发现，NTM的环境小生境是最相关的高度膨胀，潮湿的土壤含有高水平的铁氧化物/氢氧化物。了解与自然环境中NTM存在相关的因素对于确定与NTM渗透到供水系统相关的潜在机制和风险因素至关重要，这些供水系统最终被输送到被认为存在最大暴露风险的家庭。
Nontuberculous mycobacteria (NTM) are opportunistic pathogens that cause chronic pulmonary disease (PD). NTM infections are thought to be acquired from the environment; however, the basal environmental factors that drive and sustain NTM prevalence are not well understood. The highest prevalence of NTM PD cases in the United States is reported from Hawai’i, which is unique in its climate and soil composition, providing an opportunity to investigate the environmental drivers of NTM prevalence. We used microbiological sampling and spatial logistic regression complemented with fine-scale soil mineralogy to model the probability of NTM presence across the natural landscape of Hawai’i. Over 7 years, we collected and microbiologically cultured 771 samples from 422 geographic sites in natural areas across the Hawaiian Islands for the presence of NTM. NTM were detected in 210 of these samples (27%), with Mycobacterium abscessus being the most frequently isolated species. The probability of NTM presence was highest in expansive soils (those that swell with water) with a high water balance (>1-m difference between rainfall and evapotranspiration) and rich in Fe-oxides/hydroxides. We observed a positive association between NTM presence and iron in wet soils, supporting past studies, but no such association in dry soils. High soil-water balance may facilitate underground movement of NTM into the aquifer system, potentially compounded by expansive capabilities allowing crack formation under drought conditions, representing further possible avenues for aquifer infiltration. These results suggest both precipitation and soil properties are mechanisms by which surface NTM may reach the human water supply.IMPORTANCENontuberculous mycobacteria (NTM) are ubiquitous in the environment, being found commonly in soils and natural bodies of freshwater. However, little is known about the environmental niches of NTM and how they relate to NTM prevalence in homes and other human-dominated areas. To characterize NTM environmental associations, we collected and cultured 771 samples from 422 geographic sites in natural areas across Hawai’i, the U.S. state with the highest prevalence of NTM pulmonary disease. We show that the environmental niches of NTM are most associated with highly expansive, moist soils containing high levels of iron oxides/hydroxides. Understanding the factors associated with NTM presence in the natural environment will be crucial for identifying potential mechanisms and risk factors associated with NTM infiltration into water supplies, which are ultimately piped into homes where most exposure risk is thought to occur.
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夏威夷月平均降雨量的地理分布*
DOI：
10.1007/978-1-940033-01-3_3
发表时间：
1951
期刊：
Journal of Geophysical Research: Atmospheres
影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
2.4
作者：
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LeJeune, J.
DOI：
10.1002/joc.4437
发表时间：
2016-03-15
期刊：
INTERNATIONAL JOURNAL OF CLIMATOLOGY
影响因子：
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作者：
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通讯作者：
Needham, Heidi L.