Increased Serum Cystatin C in Early Parkinson's Disease with Objective Sleep Disturbances.
Increased Serum Cystatin C in Early Parkinson's Disease with Objective Sleep Disturbances.
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伴有客观睡眠障碍的早期帕金森病患者血清胱抑素 C 升高
DOI：
10.4103/0366-6999.229902
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发表时间：
2018-04-20
影响因子：
6.1
通讯作者：
Liu CF
中科院分区：
文献类型：
--
作者：
Xiong KP;Dai YP;Chen J;Xu JM;Wang Y;Feng P;You SJ;Liu CF
背景：睡眠障碍是导致帕金森病（PD）患者残疾的主要非运动症状之一。半胱氨酸蛋白酶抑制剂C（CysC）是一种比血清肌酐或估计肾小球滤过率更敏感的生物标志物。先前的研究已经报道了神经退行性疾病和睡眠障碍中CysC水平的改变。本研究旨在探讨帕金森病早期患者血清CysC水平与客观睡眠障碍的相关性。方法：我们招募了106名早期PD患者和146名年龄和性别匹配的对照。所有参与者都接受了临床调查和视频多导睡眠图。测定睡眠参数和血清CysC水平。然后，我们调查了早期PD患者中CysC与临床变量和客观睡眠障碍之间的关系。结果如下：早期PD患者血清CysC水平（1.03 ± 0.19 mg/L）显著高于对照组（0.96 ± 0.15 mg/L，P = 0.009）。早期PD患者血清CysC水平与年龄（r = 0.334，P < 0.001）、性别（r = 0.264，P = 0.013）、肌酐水平（r = 0.302，P = 0.018）呈正相关。早期PD患者血清CysC水平升高与呼吸暂停低通气指数（AHI）升高显著相关（r = 0.231，P = 0.017），尤其是呼吸暂停低通气指数升高（r = 0.333，P < 0.001）。早期PD患者血清CysC水平升高与血氧饱和度下降指数（r = 0.223，P = 0.021）、血氧饱和度（SaO 2）<90%的时间百分比（r = 0.644，P < 0.001）、睡眠中觉醒和呼吸事件（r = 0.247，P = 0.013）呈正相关。相反，PD患者血清CysC水平升高与平均和最小SaO 2呈负相关（r =-0.323，-0.315，P均= 0.001）。结论：早期PD患者血清CysC水平较高。血清CysC水平升高的PD患者有更多的呼吸事件和更严重的氧饱和度下降。因此，血清CysC水平可以预测早期PD患者睡眠呼吸障碍的严重程度。
Background: Sleep disturbance is one of the major non-motor symptoms which cause the disability of Parkinson's disease (PD) patients. Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate. Previous studies have reported altered CysC levels in neurodegenerative disorders and sleep disorders. This study aimed to explore the correlations of serum CysC levels and objective sleep disturbances in early PD. Methods: We recruited 106 early PD patients and 146 age- and sex-matched controls. All participants underwent clinical investigation and video-polysomnography. Sleep parameters and serum levels of CysC were measured. Then, we investigated the relationships between CysC and clinical variables and objective sleep disturbances in early PD patients. Results: The mean serum level of CysC was significantly higher in patients with early PD (1.03 ± 0.19 mg/L) compared to controls (0.96 ± 0.15 mg/L, P = 0.009). There were significantly positive correlations between serum CysC levels and age (r = 0.334, P < 0.001), gender (r = 0.264, P = 0.013), and creatinine levels (r = 0.302, P = 0.018) in early PD patients. Increased serum CysC levels in early PD patients were significantly associated with higher apnea and hypopnea index (AHI) (r = 0.231, P = 0.017), especially hypopnea index (r = 0.333, P < 0.001). In early PD patients, elevated serum CysC levels were positively correlated with oxygen desaturation index (r = 0.223, P = 0.021), percentage of time spent at oxygen saturation (SaO2) <90% (r = 0.644, P < 0.001), arousal with respiratory event during sleep (r = 0.247, P = 0.013). On the contrary, the elevated serum CysC levels were negatively correlated with mean and minimal SaO2 (r = −0.323, −0.315, both P = 0.001) in PD patients. Conclusions: The level of serum CysC was higher in early PD patients. PD patients with elevated serum CysC levels had more respiratory events and more severe oxygen desaturation. Therefore, the serum CysC levels may predict the severities of sleep-disordered breathing problems in early PD patients.
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半胱氨酸蛋白酶抑制剂 C 诱导自噬：一种保护小鼠原代皮质神经元和神经元细胞系的机制。
影响因子：
3.7
作者：
Tizon B;Sahoo S;Yu H;Gauthier S;Kumar AR;Mohan P;Figliola M;Pawlik M;Grubb A;Uchiyama Y;Bandyopadhyay U;Cuervo AM;Nixon RA;Levy E
通讯作者：
Levy E
影响因子：
5.1
作者：
Thakur, Poonam;Nehru, Bimla
通讯作者：
Nehru, Bimla
DOI：
10.1053/j.ajkd.2013.05.022
发表时间：
2014-01
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Ensrud KE;Parimi N;Fink HA;Ishani A;Taylor BC;Steffes M;Cauley JA;Lewis CE;Orwoll ES;Osteoporotic Fractures in Men Study Group
通讯作者：
Osteoporotic Fractures in Men Study Group
影响因子：
4.3
作者：
Berry, Richard B.;Budhiraja, Rohit;Tangredi, Michelle M.
通讯作者：
Tangredi, Michelle M.
伴有或不伴有快速动眼睡眠行为障碍的帕金森病的临床特征
影响因子：
12.6
作者：
Liu Y;Zhu XY;Zhang XJ;Kuo SH;Ondo WG;Wu YC
通讯作者：
Wu YC