Poststroke fatigue and depression are related to mortality in young adults: a cohort study.
Poststroke fatigue and depression are related to mortality in young adults: a cohort study.
复制标题
DOI：
10.1136/bmjopen-2012-002404
复制
发表时间：
2013-03-01
期刊：
影响因子：
2.9
通讯作者：
Nyland H
中科院分区：
文献类型：
--
作者：
Naess H;Nyland H
在一项以人群为基础的研究中，探讨年轻缺血性卒中患者卒中后疲劳与抑郁和随后死亡率之间的关系。前瞻性队列研究。所有幸存的年轻缺血性中风患者生活在霍达兰县。中风时年龄在15-50岁的年轻缺血性中风患者被邀请在指数中风后平均6年进行随访。 记录了心理社会因素和危险因素。通过疲劳严重程度量表（FSS）对疲劳进行自我评估。采用蒙哥马利抑郁量表（MADRS）评定抑郁症状。未进行干预。随访死亡率。共纳入190例患者。随访时的平均年龄为48岁，随后的随访期为12年。 考克斯回归分析显示，死亡率与年龄（p =0.06）和性别（p=0.19）调整后的FSS评分（p =0.005）相关。考克斯回归分析显示，在调整年龄（p =0.10）和性别（p= 0.11）后，死亡率与MADRS评分相关（p =0.006）。疲劳和抑郁与年轻缺血性卒中患者的长期死亡率相关。由于心理社会因素和不健康的生活方式，抑郁症可能与较高的死亡率有关，而疲劳与死亡率之间的联系更广泛，包括与糖尿病、心肌梗死和心理社会因素的联系。
To investigate the relationship between poststroke fatigue and depression and subsequent mortality in young ischaemic stroke patients in a population-based study. A prospective cohort study. All surviving young ischaemic stroke patients living in Hordaland County. Young ischaemic stroke patients aged 15–50 years at the time of the stroke were invited to a follow-up on an average 6 years after the index stroke. Psychosocial factors and risk factors were registered. Fatigue was self-assessed by the Fatigue Severity Scale (FSS). Depression was measured by Montgomery-Åsberg Depression Rating Scale (MADRS). No intervention was performed. Mortality on follow-up. In total, 190 patients were included. The mean age on follow-up was 48 years and subsequent follow-up period was 12 years. Cox regression analysis showed that mortality was associated with FSS score (p=0.005) after adjusting for age (p=0.06) and sex (p=0.19). Cox regression analysis showed that mortality was associated with MADRS score (p=0.006) after adjusting for age (p=0.10) and sex (p=0.11). Both fatigue and depression are associated with long-term mortality in young adults with ischaemic stroke. Depression may be linked to higher mortality because of psychosocial factors and unhealthy lifestyles whereas the link between fatigue and mortality is broader including connection to diabetes mellitus, myocardial infarction and psychosocial factors.
登录
查看更多内容
影响因子：
8.3
作者：
Glader, EL;Stegmayr, B;Asplund, K
通讯作者：
Asplund, K
影响因子：
8.3
作者：
JOHNSON, CJ;KITTNER, SJ;PRICE, TR
通讯作者：
PRICE, TR
影响因子：
8.3
作者：
Putaala, Jukka;Curtze, Sami;Tatlisumak, Turgut
通讯作者：
Tatlisumak, Turgut
影响因子：
8.3
作者：
Herrmann, N;Black, SE;Szalai, JP
通讯作者：
Szalai, JP
影响因子：
5.8
作者：
Téllez, N;Río, J;Montalbal, X
通讯作者：
Montalbal, X