Diffuse Idiopathic Skeletal Hyperostosis of Cervical Spine with Dysphagia-Molecular and Clinical Aspects.

Diffuse Idiopathic Skeletal Hyperostosis of Cervical Spine with Dysphagia-Molecular and Clinical Aspects.
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DOI:
10.3390/ijms22084255
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发表时间:
2021-04-20
影响因子:
5.6
通讯作者:
Kubaszewski Ł
Kubaszewski Ł
中科院分区:
生物学2区
文献类型:
--
作者:
Dąbrowski M;Kubaszewski Ł

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弥漫性特发性骨肥厚(DISH)是一种以颈椎韧带钙化和骨化为特征的疾病;在某些情况下,它可能导致吞咽困难。这种情况在50岁以上患有代谢紊乱的男性中更常见,通常无症状,对患者来说不是一个大问题。DISH的病因学知之甚少,已知的遗传因素表明多个信号通路和多基因遗传。在这篇综述中,我们讨论了DISH的流行病学,临床和病因学方面,特别关注吞咽困难。
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the calcification and ossification of the ligaments of the cervical spine; in some cases, it may result in dysphagia. The condition is more common in men over 50 years of age with metabolic disorders, and it is often asymptomatic and not a major issue for patients. The etiology of DISH is poorly understood, and known genetic factors indicate multiple signal pathways and multigene inheritance. In this review, we discuss the epidemiological, clinical, and etiological aspects of DISH with a special focus on dysphagia.
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