MicroRNA function in craniofacial bone formation, regeneration and repair.
MicroRNA function in craniofacial bone formation, regeneration and repair.
复制标题
microRNA在颅面骨形成、再生和修复中的作用
DOI:
10.1016/j.bone.2020.115789
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发表时间:
2021-03
期刊:
影响因子:
4.1
通讯作者:
Amendt BA
中科院分区:
文献类型:
--
作者:
Hong L;Sun H;Amendt BA
Bone formation in the craniofacial complex is regulated by cranial neural crest (CNC) and mesoderm-derived cells. Different elements of the developing skull, face, mandible, maxilla (jaws) and nasal bones are regulated by an array of transcription factors, signaling molecules and microRNAs (miRs). miRs are molecular modulators of these factors and act to restrict their expression in a temporal-spatial mechanism. miRs control the different genetic pathways that form the craniofacial complex. By understanding how miRs function in vivo during development they can be adapted to regenerate and repair craniofacial genetic anomalies as well as bone diseases and defects due to traumatic injuries. This review will highlight some of the new miR technologies and functions that form new bone or inhibit bone regeneration.
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