Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8(+) T Cells by Persistent Viruses and Vaccines.
Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8(+) T Cells by Persistent Viruses and Vaccines.
复制标题
DOI：
10.1016/j.celrep.2018.03.074
复制
发表时间：
2018-04-17
期刊：
影响因子：
8.8
通讯作者：
Klenerman P
中科院分区：
文献类型：
--
作者：
Gordon CL;Lee LN;Swadling L;Hutchings C;Zinser M;Highton AJ;Capone S;Folgori A;Barnes E;Klenerman P
T细胞记忆的诱导和维持对于疫苗的成功至关重要。最近描述的一个记忆CD 8 + T细胞的子集定义的趋化因子受体CX 3CR 1的中间表达被证明具有自我更新，增殖，和组织监视特性相关的疫苗诱导的记忆。当记忆维持在高水平时，我们跟踪了这些细胞：巨细胞病毒（CMV）和腺病毒载体疫苗诱导的记忆膨胀。在小鼠中，CMV和疫苗诱导的膨胀T细胞均显示出持续高水平的CX 3R 1 int细胞，其在早期记忆中表现出效应记忆表型，这是膨胀池的特征。在人类中，CX 3CR 1 int CD 8 + T细胞在丙型肝炎病毒（HCV）（ChAd 3-NSmut）的腺病毒载体疫苗接种后和自然CMV感染期间被强烈诱导，并与小鼠中类似的记忆表型相关。这些数据表明，CX 3CR 1 int细胞形成了小鼠和人类对持久性病毒和疫苗的记忆池的重要组成部分。CX 3CR 1 int T细胞是由CMV和腺疫苗诱导的记忆的主要组成部分膨胀的CX 3CR 1 int细胞表现出效应记忆表型，但可以增殖由CMV和腺疫苗诱导的人类膨胀的CX 3CR 1 int细胞共享特征CX 3CR 1 int细胞有助于特定感染或疫苗中的记忆扩展Gordon et al.证明了CX 3CR 1 int外周记忆T细胞是由持续性CMV和腺病毒疫苗接种诱导的记忆膨胀的重要组成部分。其特征在于持续增殖和与这些扩展的CD 8 + T细胞记忆应答相关的效应记忆表型。核心表型特征是人类和小鼠共有的。
The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells when memory is sustained at high levels: memory inflation induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools, in early memory. In humans, CX3CR1int CD8+ T cells were strongly induced following adenovirus-vectored vaccination for hepatitis C virus (HCV) (ChAd3-NSmut) and during natural CMV infection and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int cells form an important component of the memory pool in response to persistent viruses and vaccines in both mice and humans. CX3CR1int T cells are a large component of memory induced by CMV and adenovaccines Inflating CX3CR1int cells exhibit an effector-memory phenotype but can proliferate Human inflationary CX3CR1int cells induced by CMV and adenovaccines share features CX3CR1int cells contribute to memory expansion in specific infections or vaccines Gordon et al. demonstrate that CX3CR1int peripheral memory T cells are a substantial component of memory inflation induced by persistent CMVs and adenoviral vaccination. They are characterized by sustained proliferation and an effector-memory phenotype linked to these expanded CD8+ T cell memory responses. Core phenotypic features are shared by humans and mice.
登录
查看更多内容
影响因子：
30.3
作者：
Daley-Bauer LP;Roback LJ;Wynn GM;Mocarski ES
通讯作者：
Mocarski ES
影响因子：
17.1
作者：
Swadling L;Capone S;Antrobus RD;Brown A;Richardson R;Newell EW;Halliday J;Kelly C;Bowen D;Fergusson J;Kurioka A;Ammendola V;Del Sorbo M;Grazioli F;Esposito ML;Siani L;Traboni C;Hill A;Colloca S;Davis M;Nicosia A;Cortese R;Folgori A;Klenerman P;Barnes E
通讯作者：
Barnes E
DOI：
10.1126/science.aac9475
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hansen SG;Wu HL;Burwitz BJ;Hughes CM;Hammond KB;Ventura AB;Reed JS;Gilbride RM;Ainslie E;Morrow DW;Ford JC;Selseth AN;Pathak R;Malouli D;Legasse AW;Axthelm MK;Nelson JA;Gillespie GM;Walters LC;Brackenridge S;Sharpe HR;López CA;Früh K;Korber BT;McMichael AJ;Gnanakaran S;Sacha JB;Picker LJ
通讯作者：
Picker LJ
影响因子：
5.3
作者：
Jung, S;Aliberti, J;Littman, DR
通讯作者：
Littman, DR
影响因子：
32.4
作者：
Gerlach, Carmen;Moseman, E. Ashley;Loughhead, Scott M.;Alvarez, David;Zwijnenburg, Anthonie J.;Waanders, Lisette;Garg, Rohit;de la Torre, Juan C.;von Andrian, Ulrich H.
通讯作者：
von Andrian, Ulrich H.