IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice.
IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice.
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IL-15 增强树突状表皮 T 细胞的激活和 IGF-1 的产生，促进糖尿病小鼠的伤口愈合
DOI：
10.3389/fimmu.2017.01557
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发表时间：
2017
影响因子：
7.3
通讯作者：
He W
中科院分区：
文献类型：
--
作者：
Wang Y;Bai Y;Li Y;Liang G;Jiang Y;Liu Z;Liu M;Hao J;Zhang X;Hu X;Chen J;Wang R;Yin Z;Wu J;Luo G;He W
树突状表皮T细胞（DETC）的稳态改变和功能障碍有助于异常糖尿病伤口愈合。IL-15在T淋巴细胞的存活和活化中起重要作用。最近，表皮IL-15的减少已被报道为链脲佐菌素诱导的糖尿病动物中异常DETC稳态的重要机制。然而，IL-15在受损的糖尿病伤口愈合中的作用仍然未知。在这里，我们发现，通过挽救DETC的活化不足，IL-15增加了DETC产生的IGF-1，从而促进糖尿病皮肤伤口修复。IL-15对DETC中IGF-1的调节部分依赖于mTOR通路。此外，受伤表皮中IL-15和IGF-1的表达呈正相关。总之，我们的数据表明IL-15通过DETC增强IGF-1的产生以促进糖尿病伤口修复，表明IL-15作为管理糖尿病伤口愈合的潜在治疗剂。
Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing.
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影响因子：
2.2
作者：
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通讯作者：
Bitar, MS
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作者：
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