The pursuit of a scalable nanofabrication platform for use in material and life science applications.
The pursuit of a scalable nanofabrication platform for use in material and life science applications.
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DOI：
10.1021/ar8000348
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发表时间：
2008-12
影响因子：
18.3
通讯作者：
Desimone, Joseph M.
中科院分区：
文献类型：
--
作者：
Gratton, Stephanie E. A.;Williams, Stuart S.;Napier, Mary E.;Pohlhaus, Patrick D.;Zhou, Zhilian;Wiles, Kenton B.;Maynor, Benjamin W.;Shen, Clifton;Olafsen, Tove;Samulski, Edward T.;Desimone, Joseph M.
在这个帐户中，我们描述了使用全氟聚醚（PFPE）为基础的材料，能够准确地模具和复制微米和纳米级的功能，使用传统的技术，如压花以及新技术，我们开发的利用氟化基板的特殊表面特性。由于PFPE独特的部分润湿和非润湿特性，我们能够超越通常的模塑和压印光刻方法，并创建了一种称为PRINT（非润湿模板中的粒子[或图案]复制）的技术。PRINT是一种独特的“自上而下”的制造技术，能够生成孤立的颗粒，颗粒阵列和图案化特征阵列，用于纳米医学和材料科学中的大量应用。PRINT技术的一个特殊优势是对定义明确的颗粒进行高分辨率成型，并对尺寸、形状、变形性和表面化学进行精确控制。获得的复制水平展示了PFPE模塑材料的一些独特特性。特别地，这些材料由具有正铺展系数的非常低的表面能前体产生，可以在环境温度下光固化，并且具有最低的粘合性、不溶胀性和适形性。这些独特的功能使材料具有独特的属性和纳米分辨率，具有前所未有的科学和技术价值。例如，在纳米医学中，使用PFPE材料与PRINT技术使我们能够设计颗粒，其中我们可以定制关键的治疗参数，如生物利用度，生物分布，靶向特异性细胞渗透和受控货物释放。类似地，在材料科学中，我们可以制造光学薄膜和透镜阵列，复制复杂的自然存在的物体，如腺病毒颗粒，并创建无机氧化物的2D图案阵列。
In this Account, we describe the use of perfluoropolyether (PFPE)-based materials that are able to accurately mold and replicate micro- and nanosized features using traditional techniques such as embossing as well as new techniques that we developed to exploit the exceptional surface characteristics of fluorinated substrates. Because of the unique partial wetting and nonwetting characteristics of PFPEs, we were able to go beyond the usual molding and imprint lithography approaches and have created a technique called PRINT (Particle [or Pattern] Replication In Nonwetting Templates). PRINT is a distinctive “top-down” fabrication technique capable of generating isolated particles, arrays of particles, and arrays of patterned features for a plethora of applications in both nanomedicine and materials science. A particular strength of the PRINT technology is the high-resolution molding of well-defined particles with precise control over size, shape, deformability, and surface chemistry. The level of replication obtained showcases some of the unique characteristics of PFPE molding materials. In particular, these materials arise from very low surface energy precursors with positive spreading coefficients, can be photocured at ambient temperature, and are minimally adhesive, nonswelling, and conformable. These distinctive features enable the molding of materials with unique attributes and nanometer resolution that have unprecedented scientific and technological value. For example, in nanomedicine, the use of PFPE materials with the PRINT technique allows us to design particles in which we can tailor key therapeutic parameters such as bioavailability, biodistribution, target-specific cell penetration, and controlled cargo release. Similarly, in materials science, we can fabricate optical films and lens arrays, replicate complex, naturally occurring objects such as adenovirus particles, and create 2D patterned arrays of inorganic oxides.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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Hampton, Meredith J.;Williams, Stuart S.;DeSimone, Joseph M.
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作者：
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通讯作者：
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