Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.
Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.
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DOI：
10.1289/ehp.0901582
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发表时间：
2010-06
影响因子：
10.4
通讯作者：
Grandjean P
中科院分区：
文献类型：
--
作者：
Harari R;Julvez J;Murata K;Barr D;Bellinger DC;Debes F;Grandjean P
产前接触杀虫剂造成的长期神经毒性风险尚不清楚，但之前对厄瓜多尔学龄儿童进行的一项试点研究表明，血压和视觉空间处理可能是脆弱的。在厄瓜多尔北部，花卉种植密集，依赖女性就业，我们进行了一项密集的横断面研究，以评估6-8岁儿童的神经行为功能。我们对当地公立学校两个年级的87名学生进行了一系列神经行为测试。关于怀孕期间农药暴露的信息是从母亲访谈中获得的。通过尿液中有机磷代谢产物的排泄和红细胞乙酰胆碱酯酶活性来评估儿童目前的农药暴露情况。在84名符合条件的参与者中，35人在怀孕期间通过母亲的职业接触接触到杀虫剂，23人通过父亲的工作间接接触。22名儿童无论他们的产前暴露状态如何，都有可检测到的当前暴露。只有出生前接触过母体温室工作的儿童在协变量调整后表现出一致的缺陷，其中包括发育迟缓和社会经济变量。与暴露相关的缺陷在运动速度(手指敲击任务)、运动协调(Santa Ana Form Board)、视觉空间表现(Stanford-Bnet Copy Testing)和视觉记忆(Stanford-Bnet Copy Recall Test)方面最强。这些联系相当于发育延迟1.5-2年。出生前接触杀虫剂也与收缩压平均升高3.6毫米汞柱和体重指数轻微下降1.1公斤/平方米显著相关。纳入试点数据加强了这些结果。这些发现支持了这样的观点，即产前接触杀虫剂--在不会对母亲产生不利健康后果的水平上--可能会对儿童的大脑发育造成持久的不利影响。因此，接触杀虫剂可能会导致发育神经毒性的“无声大流行”。
The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable. In northern Ecuador, where floriculture is intensive and relies on female employment, we carried out an intensive cross-sectional study to assess children’s neurobehavioral functions at 6–8 years of age. We examined all 87 children attending two grades in the local public school with an expanded battery of neurobehavioral tests. Information on pesticide exposure during the index pregnancy was obtained from maternal interview. The children’s current pesticide exposure was assessed from the urinary excretion of organophosphate metabolites and erythrocyte acetylcholine esterase activity. Of 84 eligible participants, 35 were exposed to pesticides during pregnancy via maternal occupational exposure, and 23 had indirect exposure from paternal work. Twenty-two children had detectable current exposure irrespective of their prenatal exposure status. Only children with prenatal exposure from maternal greenhouse work showed consistent deficits after covariate adjustment, which included stunting and socioeconomic variables. Exposure-related deficits were the strongest for motor speed (Finger Tapping Task), motor coordination (Santa Ana Form Board), visuospatial performance (Stanford-Binet Copying Test), and visual memory (Stanford-Binet Copying Recall Test). These associations corresponded to a developmental delay of 1.5–2 years. Prenatal pesticide exposure was also significantly associated with an average increase of 3.6 mmHg in systolic blood pressure and a slight decrease in body mass index of 1.1 kg/m2. Inclusion of the pilot data strengthened these results. These findings support the notion that prenatal exposure to pesticides—at levels not producing adverse health outcomes in the mother—can cause lasting adverse effects on brain development in children. Pesticide exposure therefore may contribute to a “silent pandemic” of developmental neurotoxicity.
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影响因子：
5.4
作者：
Handal, Alexis J.;Lozoff, Betsy;Harlow, Sioban D.
通讯作者：
Harlow, Sioban D.
年轻墨西哥裔美国儿童的有机磷酸农药暴露和神经发育。
影响因子：
10.4
作者：
Eskenazi, Brenda;Marks, Amy R.;Bradman, Asa;Harley, Kim;Barr, Dana B.;Johnson, Caroline;Morga, Norma;Jewell, Nicholas A.
通讯作者：
Jewell, Nicholas A.
影响因子：
2.5
作者：
Bravo, R;Driskell, WJ;Barr, DB
通讯作者：
Barr, DB
DOI：
10.1186/1476-069x-7-50
发表时间：
2008-10-22
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Bjørling-Poulsen M;Andersen HR;Grandjean P
通讯作者：
Grandjean P
影响因子：
10.4
作者：
Grandjean, P;White, RF;Santos, ECD
通讯作者：
Santos, ECD